skip to main content
Idioma:

Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial

Saglam, Ebru ; Ozsagir, Zeliha Betul ; Unver, Tugba ; Alinca, Suzan Bayer ; Toprak, Ali ; Tunali, Mustafa

Journal of applied oral science, 2021-01, Vol.29, p.e20210180-e20210180 [Periódico revisado por pares]

Brazil: Faculdade De Odontologia De Bauru - USP

Texto completo disponível

Citações Citado por
  • Título:
    Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial
  • Autor: Saglam, Ebru ; Ozsagir, Zeliha Betul ; Unver, Tugba ; Alinca, Suzan Bayer ; Toprak, Ali ; Tunali, Mustafa
  • Assuntos: Corticosteroid ; DENTISTRY, ORAL SURGERY & MEDICINE ; Humans ; Lichen Planus, Oral - drug therapy ; Oral lichen planus ; Original ; Patient reported outcome measures ; Platelet-Rich Fibrin ; Wound healing
  • É parte de: Journal of applied oral science, 2021-01, Vol.29, p.e20210180-e20210180
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    ObjectType-News-3
    content type line 23
    Authors’ contributions
    Saglam, Ebru: Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Methodology (Equal); Project administration (Equal); Software (Equal); Validation (Equal); Writing-original draft (Equal); Writing-review & editing (Equal). Özsağır, Zeliha Betül: Conceptualization (Equal); Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Methodology (Equal); Resources (Equal); Software (Equal); Writing-original draft (Equal). Ünver, Tuğba: Conceptualization (Equal); Investigation (Equal); Methodology (Equal); Writing-original draft (Equal). Bayer Alınca, Suzan: Conceptualization (Equal); Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Methodology (Equal); Visualization (Equal). Toprak, Ali: Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Methodology (Equal); Software (Equal); Validation (Equal). Tunalı, Mustafa: Conceptualization (Equal); Data curation (Equal); Methodology (Equal); Project administration (Equal); Supervision (Equal); Validation (Equal); Visualization (Equal); Writing-review & editing (Equal).
    The authors declare no conflict of interest.
    Conflict of interest
  • Descrição: Our study compared the effects of injectable platelet-rich fibrin (i-PRF) with those of corticosteroids in the treatment of erosive oral lichen planus (EOLP). This split-mouth study included 24 individuals diagnosed histopathologically with bilateral EOLP. One bilateral lesion was injected with i-PRF, whereas the other was injected with methylprednisolone acetate in four sessions at 15-day intervals. Visual analog scale (VAS) for pain and satisfaction, oral health impact profile scale-14, and the lesion size were used. The intragroup comparisons showed a significant decrease in VAS-pain and lesion size in both the i-PRF group (from 81.88±17.74 to 13.33±18.34, and from 4.79±0.41 to 1.88±1.08, respectively) and the corticosteroid group (from 80.21±17.35 to 23.33±26.81, and from 4.71±0.46 to 2.21±1.35, respectively) in the 6th month compared to baseline (p<0.001). Moreover, VAS-satisfaction increased significantly in both the i-PRF group (from 26.67±17.8 to 85.63±16.24) and the corticosteroid group (from 28.33±17.05 to 74.38±24.11) in the 6th month compared to baseline (p<0.001). However, no significant difference in any value occurred in the intergroup comparisons. In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. Therefore, the use of i-PRF may be considered an option in cases refractory to topical corticosteroid therapy. Biochemical and histopathological studies are required to reveal the mechanism of i-PRF action in EOLP treatment.
  • Editor: Brazil: Faculdade De Odontologia De Bauru - USP
  • Idioma: Inglês;Português
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.