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The history of Toll-like receptors - redefining innate immunity

O'Neill, Luke A J ; Golenbock, Douglas ; Bowie, Andrew G

Nature reviews. Immunology, 2013-06, Vol.13 (6), p.453-460 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
The history of Toll-like receptors - redefining innate immunity
Autor: O'Neill, Luke A J ; Golenbock, Douglas ; Bowie, Andrew G
Assuntos: Animals ; Cyclic AMP Response Element-Binding Protein - immunology ; Cyclic AMP Response Element-Binding Protein - metabolism ; Cytokines - immunology ; Cytokines - metabolism ; Health aspects ; Humans ; Immunity, Innate - immunology ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Interferon Regulatory Factor-3 ; Interferon Regulatory Factor-7 ; Mitogen-Activated Protein Kinases - immunology ; Mitogen-Activated Protein Kinases - metabolism ; Models, Immunological ; Natural immunity ; NF-kappa B - immunology ; NF-kappa B - metabolism ; Physiological aspects ; Protein Isoforms - immunology ; Protein Isoforms - metabolism ; Signal Transduction - immunology ; Structure ; Toll-like receptors ; Toll-Like Receptors - immunology ; Toll-Like Receptors - metabolism ; Transcription Factor AP-1 - immunology ; Transcription Factor AP-1 - metabolism
É parte de: Nature reviews. Immunology, 2013-06, Vol.13 (6), p.453-460
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
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Descrição: The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.
Editor: England: Nature Publishing Group
Idioma: Inglês

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The history of Toll-like receptors - redefining innate immunity

O'Neill, Luke A J ; Golenbock, Douglas ; Bowie, Andrew G

England: Nature Publishing Group

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