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Antiarrhythmic drug effectiveness. Proposal for a new approach based on pharmacological hourly effects

Maia, I G ; Seixas, T N ; Costa, A M ; Perez, A K ; Alves, P A

Arquivos brasileiros de cardiologia, 1995-06, Vol.64 (6), p.525-531 [Periódico revisado por pares]

Brazil

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  • Título:
    Antiarrhythmic drug effectiveness. Proposal for a new approach based on pharmacological hourly effects
  • Autor: Maia, I G ; Seixas, T N ; Costa, A M ; Perez, A K ; Alves, P A
  • Assuntos: Adult ; Aged ; Anti-Arrhythmia Agents - pharmacology ; Anti-Arrhythmia Agents - therapeutic use ; Arrhythmias, Cardiac - drug therapy ; Autonomic Nervous System - physiology ; Circadian Rhythm - drug effects ; Double-Blind Method ; Electrocardiography, Ambulatory ; Female ; Humans ; Male ; Middle Aged ; Sotalol - pharmacology ; Sotalol - therapeutic use
  • É parte de: Arquivos brasileiros de cardiologia, 1995-06, Vol.64 (6), p.525-531
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    ObjectType-News-3
    content type line 23
  • Descrição: To use a new approach in order to assess the antiarrhythmic drugs, based in the hourly autonomic effects and antiarrhythmic efficacy of sotalol. Sixteen patients were evaluated in a randomized double-blind placebo-controlled study. Patients were classified in group 1 (anti-arrhythmic efficacy) and group 2 (no antiarrhythmic efficacy). The following parameters were analyzed: 1) clinical variables as age, gender, cardiac disease and ventricular ectopies density; 2) drug effects on pNN50 in 24-hour and on mean hourly cardiac cycle length; 3) percentage of hourly ventricular ectopies distribution and its correlation with pNN50 and with mean hourly cardiac cycle length in all patients; 4) drug effects on mean hourly cardiac cycle length in groups 1 and 2; 5) correlation between hourly pNN50 and ventricular ectopies density after sotalol administration in groups 1 and 2; 6) hourly drug efficacy in groups 1 and 2 and correlation with pNN50. Efficacy of the drug was present in 8 (50%) patients. Sotalol significantly increased 24-hour pNN50 (placebo 5.01 +/- 2.02%; after drug, 11.70 +/- 5.59%-p < 0.001), also increasing mean hourly cardiac cycle length during the day and night, in all patients (placebo 758.25 +/- 75.68 ms; after drug 967.71 +/- 80.17 ms-p < 0.000). It was noted that patients under placebo had different autonomic tonus; group 1 showed higher sympathetic activity as compared to group 2. Hourly drug efficacy was seen in 23 of 24-hour recordings in group 1 while it was not seen at any time in group 2. Sotalol significantly increased parasympathetic cardiac activity. The anti-arrhythmic response was related to the autonomic tonus seen before and after drug administration.
  • Editor: Brazil
  • Idioma: Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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