Idioma:

Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial

Baksaas-Aasen, K. ; Gall, L. S. ; Stensballe, J. ; Juffermans, N. P. ; Curry, N. ; Maegele, M. ; Brooks, A. ; Rourke, C. ; Gillespie, S. ; Murphy, J. ; Maroni, R. ; Vulliamy, P. ; Henriksen, H. H. ; Pedersen, K. Holst ; Kolstadbraaten, K. M. ; Wirtz, M. R. ; Kleinveld, D. J. B. ; Schäfer, N. ; Chinna, S. ; Davenport, R. A. ; Naess, P. A. ; Goslings, J. C. ; Eaglestone, S. ; Stanworth, S. ; Johansson, P. I. ; Gaarder, C. ; Brohi, K.

Intensive care medicine, 2021-01, Vol.47 (1), p.49-59 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

Texto completo disponível

Citações Citado por

Enviar para

Título:
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial
Autor: Baksaas-Aasen, K. ; Gall, L. S. ; Stensballe, J. ; Juffermans, N. P. ; Curry, N. ; Maegele, M. ; Brooks, A. ; Rourke, C. ; Gillespie, S. ; Murphy, J. ; Maroni, R. ; Vulliamy, P. ; Henriksen, H. H. ; Pedersen, K. Holst ; Kolstadbraaten, K. M. ; Wirtz, M. R. ; Kleinveld, D. J. B. ; Schäfer, N. ; Chinna, S. ; Davenport, R. A. ; Naess, P. A. ; Goslings, J. C. ; Eaglestone, S. ; Stanworth, S. ; Johansson, P. I. ; Gaarder, C. ; Brohi, K.
Assuntos: Anesthesiology ; Bleeding ; Blood ; Blood Coagulation Disorders ; Brain ; Coagulation ; Comparative analysis ; Critical Care Medicine ; Emergency Medicine ; Head injuries ; Hemorrhage ; Hemorrhage - etiology ; Hemorrhage - therapy ; Hemostasis ; Hemostatics ; Humans ; Injuries ; Intensive ; Intensive care ; Medical equipment and supplies industry ; Medical examination ; Medical test kit industry ; Medicine ; Medicine & Public Health ; Mortality ; Multicenter Studies as Topic ; Original ; Pain Medicine ; Pediatrics ; Pneumology/Respiratory System ; Resuscitation ; Subgroups ; Thrombelastography ; Tranexamic acid ; Transfusion ; Trauma ; Traumatic brain injury ; United Kingdom ; United States ; Viscoelasticity ; Wounds and Injuries - complications ; Wounds and Injuries - therapy
É parte de: Intensive care medicine, 2021-01, Vol.47 (1), p.49-59
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Descrição: Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine whether augmenting MHPs with Viscoelastic Haemostatic Assays (VHA) would improve outcomes compared to Conventional Coagulation Tests (CCTs). Methods This was a multi-centre, randomized controlled trial comparing outcomes in trauma patients who received empiric MHPs, augmented by either VHA or CCT-guided interventions. Primary outcome was the proportion of subjects who, at 24 h after injury, were alive and free of massive transfusion (10 or more red cell transfusions). Secondary outcomes included 28-day mortality. Pre-specified subgroups included patients with severe traumatic brain injury (TBI). Results Of 396 patients in the intention to treat analysis, 201 were allocated to VHA and 195 to CCT-guided therapy. At 24 h, there was no difference in the proportion of patients who were alive and free of massive transfusion (VHA: 67%, CCT: 64%, OR 1.15, 95% CI 0.76–1.73). 28-day mortality was not different overall (VHA: 25%, CCT: 28%, OR 0.84, 95% CI 0.54–1.31), nor were there differences in other secondary outcomes or serious adverse events. In pre-specified subgroups, there were no differences in primary outcomes. In the pre-specified subgroup of 74 patients with TBI, 64% were alive and free of massive transfusion at 24 h compared to 46% in the CCT arm (OR 2.12, 95% CI 0.84–5.34). Conclusion There was no difference in overall outcomes between VHA- and CCT-augmented-major haemorrhage protocols.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês;Norueguês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial

Berlin/Heidelberg: Springer Berlin Heidelberg

Buscando em bases de dados remotas. Favor aguardar.