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Cullin 4-DCAF Proteins in Tumorigenesis

Sun, Yi ; Wei, Wenyi ; Jin, Jianping

Advances in experimental medicine and biology, 2020, Vol.1217, p.241-259 [Periódico revisado por pares]

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Título:
Cullin 4-DCAF Proteins in Tumorigenesis
Autor: Sun, Yi ; Wei, Wenyi ; Jin, Jianping
Assuntos: Animals ; Cancer etiology ; Carcinogenesis - genetics ; CRL4 ligase and tumorigenesis ; Cullin 4 ; Cullin Proteins - genetics ; Cullin Proteins - metabolism ; DCAF ; Humans ; Intracellular Signaling Peptides and Proteins - metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Mouse models ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Ubiquitination
É parte de: Advances in experimental medicine and biology, 2020, Vol.1217, p.241-259
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family, orchestrates a variety of critical cellular processes and pathophysiological events. Recent results from mouse genetics, clinical analyses, and biochemical studies have revealed the impact of CRL4 in development and cancer etiology and elucidated its in-depth mechanism on catalysis of ubiquitination as a ubiquitin E3 ligase. Here, we summarize the versatile roles of the CRL4 E3 ligase complexes in tumorigenesis dependent on the evidence obtained from knockout and transgenic mouse models as well as biochemical and pathological studies.
Títulos relacionados: Advances in Experimental Medicine and Biology
Editor: Singapore: Springer
Idioma: Inglês

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