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Physical Activity and Genome-wide DNA Methylation: The REgistre GIroní del COR Study

FERNÁNDEZ-SANLÉS, ALBA ; SAYOLS-BAIXERAS, SERGI ; CASTRO DE MOURA, MANUEL ; ESTELLER, MANEL ; SUBIRANA, ISAAC ; TORRES-CUEVAS, SEBASTIÁN ; PÉREZ-FERNÁNDEZ, SILVIA ; ASLIBEKYAN, STELLA ; MARRUGAT, JAUME ; ELOSUA, ROBERTO

Medicine and science in sports and exercise, 2020-03, Vol.52 (3), p.589-597 [Periódico revisado por pares]

United States: American College of Sports Medicine

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  • Título:
    Physical Activity and Genome-wide DNA Methylation: The REgistre GIroní del COR Study
  • Autor: FERNÁNDEZ-SANLÉS, ALBA ; SAYOLS-BAIXERAS, SERGI ; CASTRO DE MOURA, MANUEL ; ESTELLER, MANEL ; SUBIRANA, ISAAC ; TORRES-CUEVAS, SEBASTIÁN ; PÉREZ-FERNÁNDEZ, SILVIA ; ASLIBEKYAN, STELLA ; MARRUGAT, JAUME ; ELOSUA, ROBERTO
  • Assuntos: CpG Islands - physiology ; DNA Methylation - physiology ; Exercise - physiology ; Genome-Wide Association Study ; Humans
  • É parte de: Medicine and science in sports and exercise, 2020-03, Vol.52 (3), p.589-597
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: INTRODUCTIONDNA methylation may be one of the biological mechanisms underlying the health benefits of physical activity (PA). Our objective was to determine the association between PA and genome-wide DNA methylation at CpG level. METHODSWe designed a two-stage epigenome wide association study. In the discovery stage, we used 619 individuals from the REgistre GIroní del COR cohort. Next, we validated the CpG suggestively associated with PA (P < 10) in two independent populations (n = 1735 and 190, respectively). Physical activity was assessed with validated questionnaires and classified as light PA (LPA), moderate PA, vigorous PA, moderate-vigorous PA (MVPA) and total PA. We examined linear and nonlinear associations and meta-analyzed the results in the three populations. The linear associations were meta-analyzed with a fixed-effects model and the P values of the nonlinear associations with the Stouffer and Fisher methods. We established a P value threshold that fulfilled Bonferroni criteria over the number of CpG analyzed (0.05/421,940 = 1.185 × 10). RESULTSIn the meta-analyses, two CpG sites had a statistically significant nonlinear association with MVPA. cg24155427 (P = 1.19 × 10), located in an intergenic region in chromosome 1, has been previously associated with smoking, lupus, and aging. cg09565397 (P = 1.59 × 10), located within DGAT1 in chromosome 8, which encodes an enzyme involved in triacylglycerol synthesis. CONCLUSIONSThis population-based study identified two new, differentially methylated CpG sites with a nonlinear dose–response relationship to MVPA. These associations must be additionally validated and may be considered for further research on the biological mechanisms underlying health benefits of PA.
  • Editor: United States: American College of Sports Medicine
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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