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Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

Stirrup, Oliver ; Hughes, Joseph ; Parker, Matthew ; Partridge, David G ; Shepherd, James G ; Blackstone, James ; Coll, Francesc ; Keeley, Alexander ; Lindsey, Benjamin B ; Marek, Aleksandra ; Peters, Christine ; Singer, Joshua B ; Tamuri, Asif ; de Silva, Thushan I ; Thomson, Emma C ; Breuer, Judith

eLife, 2021-06, Vol.10 [Periódico revisado por pares]

England: eLife Sciences Publications Ltd

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Título:
Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data
Autor: Stirrup, Oliver ; Hughes, Joseph ; Parker, Matthew ; Partridge, David G ; Shepherd, James G ; Blackstone, James ; Coll, Francesc ; Keeley, Alexander ; Lindsey, Benjamin B ; Marek, Aleksandra ; Peters, Christine ; Singer, Joshua B ; Tamuri, Asif ; de Silva, Thushan I ; Thomson, Emma C ; Breuer, Judith
Assuntos: Algorithms ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; Cross Infection - diagnosis ; Cross Infection - epidemiology ; Disease Outbreaks - statistics & numerical data ; Disease transmission ; Epidemiology ; Epidemiology and Global Health ; Feedback ; Genome, Viral ; Genomics ; Health care ; healthcare associated ; Hospitals - statistics & numerical data ; Humans ; Metadata ; Microbiology and Infectious Disease ; Mutation ; Mutation rates ; nosocomial ; Nosocomial infections ; outbreak ; Phylogeny ; Population Surveillance - methods ; Probability ; Public health ; Retrospective Studies ; SARS-CoV-2 ; SARS-CoV-2 - genetics ; Severe acute respiratory syndrome coronavirus 2 ; Teams ; Tools and Resources ; United Kingdom - epidemiology ; Whole Genome Sequencing
É parte de: eLife, 2021-06, Vol.10
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Rapid identification and investigation of healthcare-associated infections (HCAIs) is important for suppression of SARS-CoV-2, but the infection source for hospital onset COVID-19 infections (HOCIs) cannot always be readily identified based only on epidemiological data. Viral sequencing data provides additional information regarding potential transmission clusters, but the low mutation rate of SARS-CoV-2 can make interpretation using standard phylogenetic methods difficult. We developed a novel statistical method and sequence reporting tool (SRT) that combines epidemiological and sequence data in order to provide a rapid assessment of the probability of HCAI among HOCI cases (defined as first positive test >48 hr following admission) and to identify infections that could plausibly constitute outbreak events. The method is designed for prospective use, but was validated using retrospective datasets from hospitals in Glasgow and Sheffield collected February-May 2020. We analysed data from 326 HOCIs. Among HOCIs with time from admission ≥8 days, the SRT algorithm identified close sequence matches from the same ward for 160/244 (65.6%) and in the remainder 68/84 (81.0%) had at least one similar sequence elsewhere in the hospital, resulting in high estimated probabilities of within-ward and within-hospital transmission. For HOCIs with time from admission 3-7 days, the SRT probability of healthcare acquisition was >0.5 in 33/82 (40.2%). The methodology developed can provide rapid feedback on HOCIs that could be useful for infection prevention and control teams, and warrants further prospective evaluation. The integration of epidemiological and sequence data is important given the low mutation rate of SARS-CoV-2 and its variable incubation period. COG-UK HOCI funded by COG-UK consortium, supported by funding from UK Research and Innovation, National Institute of Health Research and Wellcome Sanger Institute.
Editor: England: eLife Sciences Publications Ltd
Idioma: Inglês

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Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

England: eLife Sciences Publications Ltd

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