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Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells

Huang, Wu-Yang ; Liu, Ya-Mei ; Wang, Jian ; Wang, Xing-Na ; Li, Chun-Yang

Molecules (Basel, Switzerland), 2014-08, Vol.19 (8), p.12827-12841 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells
Autor: Huang, Wu-Yang ; Liu, Ya-Mei ; Wang, Jian ; Wang, Xing-Na ; Li, Chun-Yang
Assuntos: Active Transport, Cell Nucleus ; anthocyanins ; Anthocyanins - pharmacology ; Anti-Inflammatory Agents - pharmacology ; anti-inflammatory effect ; blueberry ; Blueberry Plants - chemistry ; Chemokine CCL2 - metabolism ; Drug Evaluation, Preclinical ; Glucosides - pharmacology ; Human Umbilical Vein Endothelial Cells - drug effects ; Human Umbilical Vein Endothelial Cells - immunology ; Human Umbilical Vein Endothelial Cells - metabolism ; Humans ; I-kappa B Proteins - metabolism ; Intercellular Adhesion Molecule-1 - metabolism ; malvidin-3-galactoside ; malvidin-3-glucoside ; NF-kappa B - metabolism ; NF-KappaB Inhibitor alpha ; Proteolysis ; Tumor Necrosis Factor-alpha - pharmacology ; Vaccinium ; Vascular Cell Adhesion Molecule-1 - metabolism
É parte de: Molecules (Basel, Switzerland), 2014-08, Vol.19 (8), p.12827-12841
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
Descrição: Blueberry fruits have a wide range of health benefits because of their abundant anthocyanins, which are natural antioxidants. The purpose of this study was to investigate the inhibitory effect of blueberry's two main anthocyanins (malvidin-3-glucoside and malvidin-3-galactoside) on inflammatory response in endothelial cells. These two malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-α) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mRNA levels in a concentration-dependent manner. Mv-3-glc at the concentration of 1 μM could inhibit 35.9% increased MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein in supernatant, as well as 9.88% MCP-1 and 48.6% ICAM-1 mRNA expression (p<0.05). In addition, they could decrease IκBα degradation (Mv-3-glc, Mv-3-gal, and their mixture at the concentration of 50 μM had the inhibition rate of 84.8%, 75.3%, and 43.2%, respectively, p<0.01) and block the nuclear translocation of p65, which suggested their anti-inflammation mechanism was mediated by the nuclear factor-kappa B (NF-κB) pathway. In general malvidin-3-glucoside had better anti-inflammatory effect than malvidin-3-galactoside. These results indicated that blueberry is good resource of anti-inflammatory anthocyanins, which can be promising molecules for the development of nutraceuticals to prevent chronic inflammation in many diseases.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells

Huang, Wu-Yang ; Liu, Ya-Mei ; Wang, Jian ; Wang, Xing-Na ; Li, Chun-Yang

Switzerland: MDPI AG

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