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Improvements to microbial productivity by analysis of metabolic fluxes

Holms, W.H ; Hamilton, I.D ; Mousdale, D

Journal of chemical technology and biotechnology (1986), 1991, Vol.50 (1), p.139-141 [Periódico revisado por pares]

London: John Wiley & Sons, Ltd

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  • Título:
    Improvements to microbial productivity by analysis of metabolic fluxes
  • Autor: Holms, W.H ; Hamilton, I.D ; Mousdale, D
  • Assuntos: Biological and medical sciences ; biomass production ; Biotechnology ; fermentation ; Fundamental and applied biological sciences. Psychology ; metabolism ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; microorganisms ; process engineering
  • É parte de: Journal of chemical technology and biotechnology (1986), 1991, Vol.50 (1), p.139-141
  • Notas: istex:2C61D5C7C38589E5BFF330F6F8C52211A87991CC
    ArticleID:JCTB280500119
    ark:/67375/WNG-8385DHRG-1
    Based on a paper presented at the meeting 'Biochemistry and Genetics for Increasing Productivities of Industrial Fermentations', held at SCI, 14/15 Belgrave Square, London SW1X 8PS, on 6 March 1990.
    ObjectType-Article-2
    SourceType-Scholarly Journals-2
    ObjectType-Feature-1
    content type line 23
    SourceType-Conference Papers & Proceedings-1
    ObjectType-Conference-3
  • Descrição: Fermentation processes use a biomass to make a desirable product. Growth of biomass and synthesis of product are usually sequential. A production strain, selected for its biosynthetic capability, is grown in a batch process. When growth ceases, feedstocks (inputs) are added continuously to sustain the metabolic fluxes through the biomass to products (outputs). Usually only one of these products is then separated downstream and processed for sale. Fluxes are channelled through specific metabolic pathways and provided these pathways are known, careful measurement of all inputs and outputs of the fermentation provides the data from which the fluxes through all the pathways can be computed. A full diagram for the central metabolic pathways can then be constructed which relates the utilisation of inputs to the provision of the precursors required to maintain the anabolic fluxes to product.
  • Editor: London: John Wiley & Sons, Ltd
  • Idioma: Inglês
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