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Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms

Oliveira, Clayton Z. ; Maiorano, Victor A. ; Marcussi, Silvana ; Sant’Ana, Carolina D. ; Januário, Ana H. ; Lourenço, Miriam V. ; Sampaio, Suely V. ; França, Suzelei C. ; Pereira, Paulo S. ; Soares, Andreimar M.

Journal of ethnopharmacology, 2005-04, Vol.98 (1), p.213-216 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms
Autor: Oliveira, Clayton Z. ; Maiorano, Victor A. ; Marcussi, Silvana ; Sant’Ana, Carolina D. ; Januário, Ana H. ; Lourenço, Miriam V. ; Sampaio, Suely V. ; França, Suzelei C. ; Pereira, Paulo S. ; Soares, Andreimar M.
Assuntos: aerial parts ; Animals ; Anticoagulant activity ; Anticoagulants - chemistry ; Anticoagulants - pharmacology ; Antifibrinogenolytic activity ; Antifibrinolytic Agents - chemistry ; Antifibrinolytic Agents - pharmacology ; Antiophidian properties ; Bauhinia ; Bauhinia - chemistry ; Bauhinia - metabolism ; Bauhinia forficata ; Bauhinia forficata extract ; bioactive properties ; Biological and medical sciences ; bites and stings ; Bothrops ; Bothrops jararacussu ; Bothrops moojeni ; Crotalid Venoms - adverse effects ; Crotalid Venoms - antagonists & inhibitors ; Crotalus durissus terrificus ; Drug Evaluation, Preclinical - methods ; Electrophoresis, Polyacrylamide Gel - methods ; General pharmacology ; Medical sciences ; Medicinal plants ; pata de vaca ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Components, Aerial - chemistry ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; snake bites ; Snake venoms ; Snake Venoms - adverse effects ; Snake Venoms - antagonists & inhibitors ; Snake Venoms - chemistry ; snakes ; venoms ; Water - chemistry ; Water - pharmacology
É parte de: Journal of ethnopharmacology, 2005-04, Vol.98 (1), p.213-216
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The aqueous extract from aerial parts of Bauhinia forficata was able to neutralize the clotting activity induced by Bothrops and Crotalus crude venoms. The clotting time, upon human plasma, induced by B. moojeni venom was significantly prolonged. Clotting and fibrinogenolytic activities induced by isolated thrombin-like enzyme from Bothrops jararacussu were totally inhibited after incubation at different ratios. The extract was not able to neutralize the hemorrhagic activity induced by an Bothrops venoms, but it efficiently inhibited the edema induced by Crotalus durissus terrificus venom and isolated PLA 2s. In addition, it did not inhibited the phospholipase A 2 activity of Bothrops snake venoms. Interaction studies between Bauhinia forficata extract and snake venoms, when analyzed by SDS-PAGE, did not reveal any apparent degradation of the venom proteins. This extract is a promising source of natural inhibitors of serine-proteases involved in blood clotting disturbances induced by snake venoms.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms

Oliveira, Clayton Z. ; Maiorano, Victor A. ; Marcussi, Silvana ; Sant’Ana, Carolina D. ; Januário, Ana H. ; Lourenço, Miriam V. ; Sampaio, Suely V. ; França, Suzelei C. ; Pereira, Paulo S. ; Soares, Andreimar M.

Shannon: Elsevier Ireland Ltd

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