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Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

Brito, J O ; Ponciano, K ; Figueroa, D ; Bernardes, N ; Sanches, I C ; Irigoyen, M C ; De Angelis, K

Brazilian journal of medical and biological research, 2008-09, Vol.41 (9), p.804-808 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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  • Título:
    Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats
  • Autor: Brito, J O ; Ponciano, K ; Figueroa, D ; Bernardes, N ; Sanches, I C ; Irigoyen, M C ; De Angelis, K
  • Assuntos: Animals ; BIOLOGY ; Blood pressure ; Female ; Female rats ; Fructose ; Fructose - administration & dosage ; Insulin resistance ; Insulin Resistance - physiology ; MEDICINE, RESEARCH & EXPERIMENTAL ; Parasympathetic nervous system ; Parasympathetic Nervous System - drug effects ; Parasympathetic Nervous System - physiopathology ; Rats ; Rats, Wistar
  • É parte de: Brazilian journal of medical and biological research, 2008-09, Vol.41 (9), p.804-808
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in the drinking water of rats for 8 weeks. Female Wistar rats (200-220 g) were divided into 2 groups: control (N = 8) and fructose-fed rats (N = 5; 100 mg/L fructose in drinking water for 8 weeks). The autonomic control of heart rate was evaluated by pharmacological blockade using atropine (3 mg/kg) and propranolol (4 mg/kg). The animals were submitted to an intravenous insulin tolerance test (ITT) and to blood glucose measurement. The fructose overload induced a significant increase in body weight (approximately 10%) and in fasting glycemia (approximately 28%). The rate constant of glucose disappearance (KITT) during ITT was lower in fructose-fed rats (3.25 +/- 0.7%/min) compared with controls (4.95 +/- 0.3%/min, P < 0.05) indicating insulin resistance. The fructose-fed group presented increased arterial pressure compared to controls (122 +/- 3 vs 108 +/- 1 mmHg, P < 0.05) and a reduction in vagal tonus (31 +/- 9 vs 55 +/- 5 bpm in controls, P < 0.05). No changes in sympathetic tonus were observed. A positive correlation, tested by the Pearson correlation, was demonstrable between cardiac vagal tonus and KITT (r = 0.8, P = 0.02). These data provided new information regarding the role of parasympathetic dysfunction associated with insulin resistance in the development of early metabolic and cardiovascular alterations induced by a high fructose diet.
  • Editor: Brazil: Associação Brasileira de Divulgação Científica
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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