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Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia

Fujiwara, Takashi ; Komatsuda, Atsushi ; Ohtani, Hiroshi ; Togashi, Masaru ; Sawada, Ken-Ichi ; Wakui, Hideki

Clinical nephrology, 2013-06, Vol.79 (6), p.494-497 [Periódico revisado por pares]

Germany

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Título:
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia
Autor: Fujiwara, Takashi ; Komatsuda, Atsushi ; Ohtani, Hiroshi ; Togashi, Masaru ; Sawada, Ken-Ichi ; Wakui, Hideki
Assuntos: Adult ; Anemia, Hemolytic, Autoimmune - drug therapy ; Anemia, Hemolytic, Autoimmune - immunology ; Anemia, Hemolytic, Autoimmune - pathology ; Antibodies, Monoclonal - blood ; Biomarkers - blood ; Biopsy ; Female ; Follow-Up Studies ; Glomerular Mesangium - immunology ; Glomerulonephritis, Membranoproliferative - drug therapy ; Glomerulonephritis, Membranoproliferative - immunology ; Glomerulonephritis, Membranoproliferative - pathology ; Glucocorticoids - therapeutic use ; Humans ; Immunoglobulin G - blood ; Immunologic Factors - blood ; Microscopy, Electron ; Pregnancy ; Pregnancy Complications, Hematologic - drug therapy ; Pregnancy Complications, Hematologic - immunology ; Pregnancy Complications, Hematologic - pathology ; Treatment Outcome
É parte de: Clinical nephrology, 2013-06, Vol.79 (6), p.494-497
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
ObjectType-Report-1
ObjectType-Article-3
Descrição: A 25-year-old woman was admitted because of proteinuria. A renal biopsy showed mesangial/endocapillary proliferative glomerulonephritis with IgG2-κ deposits. Electron microscopy showed immune complex-type deposits. She also had Coombs-positive hemolytic anemia, anticardiolipin antibodies, and antinuclear antibodies. Middle-dose steroid therapy led to improvement of proteinuria and hemolytic anemia. Six years later, she developed crescentic glomerulonephritis with IgG2-κ deposits during pregnancy. Middle-dose steroid therapy improved renal dysfunction. This is an exceptional case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a recently described rare dysproteinemia-related glomerulonephritis, associated with autoimmune disease. This case also suggests that crescentic glomerulonephritis can be superimposed on PGNMID.
Editor: Germany
Idioma: Inglês

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Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia

Fujiwara, Takashi ; Komatsuda, Atsushi ; Ohtani, Hiroshi ; Togashi, Masaru ; Sawada, Ken-Ichi ; Wakui, Hideki

Germany

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