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Expanded Criteria for Liver Transplantation in Patients with Hepatocellular Carcinoma

Kim, J.M ; Kwon, C.H.D ; Joh, J.-W ; Park, J.B ; Lee, J.H ; Kim, G.S ; Kim, S.J ; Paik, S.W ; Lee, S.-K

Transplantation proceedings, 2014-04, Vol.46 (3), p.726-729 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Expanded Criteria for Liver Transplantation in Patients with Hepatocellular Carcinoma
  • Autor: Kim, J.M ; Kwon, C.H.D ; Joh, J.-W ; Park, J.B ; Lee, J.H ; Kim, G.S ; Kim, S.J ; Paik, S.W ; Lee, S.-K
  • Assuntos: Adult ; Aged ; alpha-Fetoproteins - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - surgery ; Disease-Free Survival ; Humans ; Liver Neoplasms - metabolism ; Liver Neoplasms - surgery ; Liver Transplantation ; Middle Aged ; Recurrence ; Surgery ; Young Adult
  • É parte de: Transplantation proceedings, 2014-04, Vol.46 (3), p.726-729
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract Liver transplantation (LT) is one of the few effective treatment options for hepatocellular carcinoma (HCC). Our aim in this study was to evaluate the risk factors for HCC recurrence and propose new criteria for LT based on pretransplantation findings. One hundred eighty patients who underwent LT for HCC between 2002 and 2008 were reviewed retrospectively. Outcome measures included maximal tumor size and number of tumors revealed by radiological studies before transplantation, demographics, and tumor recurrence. Maximal tumor size >6 cm, >7 tumors, and alpha-fetoprotein (AFP) levels >1000 ng/mL were identified as independent prognostic factors of HCC recurrence in univariate and multivariate analysis. Disease-free survival rate in patients with a maximal tumor size ≤6 cm, ≤7 tumors, and/or AFP levels ≤1000 ng/mL at 1, 3, and 5 years was 97.9%, 91.5%, and 90.0%, respectively, but the 1-, 3-, and 5-year disease-free survival rate of patients who had a maximal tumor size >6 cm, >7 tumors, and/or AFP levels >1000 ng/mL was 61.9%, 47.6%, and 47.6%, respectively ( P  < .001). In conclusion, LT can improve the survival of patients with advanced HCC if they have a maximal tumor size ≤6 cm, tumor number ≤7, and/or AFP levels ≤1000 ng/mL.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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