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Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins

Rosenweig, Bradley L. ; Imamura, Takeshi ; Okadome, Toshihide ; Cox, George N. ; Yamashita, Hidetoshi ; Dijke, Peter Ten ; Heldin, Carl-Henrik ; Miyazono, Kohei

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7632-7636 [Periódico revisado por pares]

United States: National Academy of Sciences of the United States of America

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Título:
Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins
Autor: Rosenweig, Bradley L. ; Imamura, Takeshi ; Okadome, Toshihide ; Cox, George N. ; Yamashita, Hidetoshi ; Dijke, Peter Ten ; Heldin, Carl-Henrik ; Miyazono, Kohei
Assuntos: Amino Acid Sequence ; Amino acids ; Animals ; Antiserum ; Base Sequence ; Biochemistry ; Bone Morphogenetic Protein Receptors ; Bone Morphogenetic Proteins ; Bones ; Cell Line ; Cell lines ; Cloning, Molecular - methods ; Complementary DNA ; COS cells ; Deoxyribonucleic acid ; DNA ; DNA Primers ; DNA, Complementary ; Gels ; Glioblastoma ; Growth Substances - metabolism ; Ligands ; Molecular Sequence Data ; Neuroglia ; Phylogeny ; Polymerase Chain Reaction ; Proteins ; Proteins - metabolism ; Rats ; Receptors ; Receptors, Cell Surface - biosynthesis ; Receptors, Cell Surface - chemistry ; Receptors, Cell Surface - metabolism ; Receptors, Growth Factor ; Recombinant Proteins - biosynthesis ; Recombinant Proteins - chemistry ; Recombinant Proteins - metabolism ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Substantia Nigra - metabolism ; Transcription, Genetic ; Transfection
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7632-7636
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Descrição: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β superfamily. Several members of this family have been shown to transduce their signals through binding to type I and type II serine-(threonine) kinase receptors. Here we report the cDNA cloning and characterization of a human type II receptor for BMPs (BMPR-II), which is distantly related to DAF-4, a BMP type II receptor from Caenorhabditis elegans. In transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to BMPR-II. BMPR-II bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type I receptors for BMPs. Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7.
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins

Rosenweig, Bradley L. ; Imamura, Takeshi ; Okadome, Toshihide ; Cox, George N. ; Yamashita, Hidetoshi ; Dijke, Peter Ten ; Heldin, Carl-Henrik ; Miyazono, Kohei

United States: National Academy of Sciences of the United States of America

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