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Toxic Proteins in Neurodegenerative Disease

Taylor, J. Paul ; Hardy, John ; Fischbeck, Kenneth H.

Science (American Association for the Advancement of Science), 2002-06, Vol.296 (5575), p.1991-1995 [Periódico revisado por pares]

Washington, DC: American Society for the Advancement of Science

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Título:
Toxic Proteins in Neurodegenerative Disease
Autor: Taylor, J. Paul ; Hardy, John ; Fischbeck, Kenneth H.
Assuntos: Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer Disease - therapy ; Alzheimer's disease ; Alzheimers disease ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - genetics ; Amyotrophic Lateral Sclerosis - metabolism ; Amyotrophic Lateral Sclerosis - pathology ; Amyotrophic Lateral Sclerosis - therapy ; Animals ; Biological and medical sciences ; Degeneration ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease models ; Genetic mutation ; Humans ; Huntington disease ; Inclusion Bodies - metabolism ; Medical sciences ; Mutation ; Nerve degeneration ; Nervous system ; Nervous system diseases ; Nervous system heredodegenerative disorders ; Neurodegenerative diseases ; Neurodegenerative Diseases - genetics ; Neurodegenerative Diseases - metabolism ; Neurodegenerative Diseases - pathology ; Neurodegenerative Diseases - therapy ; Neurological disorders ; Neurology ; Neurons - metabolism ; Neurons - pathology ; Parkinson disease ; Parkinson Disease - genetics ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson Disease - therapy ; Parkinson's disease ; Peptides - genetics ; Peptides - metabolism ; Prion diseases ; Prion Diseases - genetics ; Prion Diseases - metabolism ; Prion Diseases - pathology ; Prion Diseases - therapy ; Protein Folding ; Proteins ; Proteins - chemistry ; Proteins - genetics ; Proteins - metabolism ; Reviews ; Tauopathies - metabolism ; Tauopathies - pathology ; Tauopathies - therapy ; Trinucleotide Repeat Expansion
É parte de: Science (American Association for the Advancement of Science), 2002-06, Vol.296 (5575), p.1991-1995
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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Descrição: A broad range of neurodegenerative disorders is characterized by neuronal damage that may be caused by toxic, aggregation-prone proteins. As genes are identified for these disorders and cell culture and animal models are developed, it has become clear that a major effect of mutations in these genes is the abnormal processing and accumulation of misfolded protein in neuronal inclusions and plaques. Increased understanding of the cellular mechanisms for disposal of abnormal proteins and of the effects of toxic protein accumulation on neuronal survival may allow the development of rational, effective treatment for these disorders.
Editor: Washington, DC: American Society for the Advancement of Science
Idioma: Inglês

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Toxic Proteins in Neurodegenerative Disease

Taylor, J. Paul ; Hardy, John ; Fischbeck, Kenneth H.

Washington, DC: American Society for the Advancement of Science

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