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AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer

Jensen‐Jarolim, E. ; Bax, H. J. ; Bianchini, R. ; Crescioli, S. ; Daniels‐Wells, T. R. ; Dombrowicz, D. ; Fiebiger, E. ; Gould, H. J. ; Irshad, S. ; Janda, J. ; Josephs, D. H. ; Levi‐Schaffer, F. ; O′Mahony, L. ; Pellizzari, G. ; Penichet, M. L. ; Redegeld, F. ; Roth‐Walter, F. ; Singer, J. ; Untersmayr, E. ; Vangelista, L. ; Karagiannis, S. N.

Allergy (Copenhagen), 2018-02, Vol.73 (2), p.328-340 [Periódico revisado por pares]

Denmark: Blackwell Publishing Ltd

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Título:
AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer
Autor: Jensen‐Jarolim, E. ; Bax, H. J. ; Bianchini, R. ; Crescioli, S. ; Daniels‐Wells, T. R. ; Dombrowicz, D. ; Fiebiger, E. ; Gould, H. J. ; Irshad, S. ; Janda, J. ; Josephs, D. H. ; Levi‐Schaffer, F. ; O′Mahony, L. ; Pellizzari, G. ; Penichet, M. L. ; Redegeld, F. ; Roth‐Walter, F. ; Singer, J. ; Untersmayr, E. ; Vangelista, L. ; Karagiannis, S. N.
Assuntos: Allergens ; allergooncology ; allergy ; Cancer ; Desensitization, Immunologic - methods ; Humans ; Hypersensitivity ; Hypersensitivity - immunology ; Hypersensitivity - therapy ; Immune clearance ; Immune system ; Immune Tolerance - immunology ; Immunological tolerance ; Immunology ; Immunotherapy ; Immunotherapy - methods ; Inflammation ; Life Sciences ; Lymphocytes T ; Neoplasms - immunology ; Neoplasms - therapy ; oncoimmunology ; Therapeutic applications ; tolerance ; Tumors
É parte de: Allergy (Copenhagen), 2018-02, Vol.73 (2), p.328-340
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição: While desired for the cure of allergy, regulatory immune cell subsets and nonclassical Th2‐biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours from immunological detection and clearance. A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune cells and mediators. We propose that research in the field of AllergoOncology that aims to delineate these immunological mechanisms with juxtaposed clinical consequences in allergy and cancer may point to novel avenues for therapeutic interventions that stand to benefit both disciplines.
Editor: Denmark: Blackwell Publishing Ltd
Idioma: Inglês

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AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer

Denmark: Blackwell Publishing Ltd

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