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Luminal glucagon-like peptide-1(7–36) amide-releasing factors in the isolated vascularly perfused rat colon

PLAISANCIE, P ; DUMOULIN, V ; CHAYVIALLE, J.-A ; CUBER, J.-C

Journal of endocrinology, 1995-06, Vol.145 (3), p.521-526 [Periódico revisado por pares]

Colchester: BioScientifica

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Título:
Luminal glucagon-like peptide-1(7–36) amide-releasing factors in the isolated vascularly perfused rat colon
Autor: PLAISANCIE, P ; DUMOULIN, V ; CHAYVIALLE, J.-A ; CUBER, J.-C
Assuntos: Animals ; Bile Acids and Salts - pharmacology ; Biological and medical sciences ; Colon - drug effects ; Colon - metabolism ; Deoxycholic Acid - pharmacology ; Dose-Response Relationship, Drug ; Endocrinology and metabolism ; Fatty Acids, Volatile - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal hormones ; Glucagon ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptides ; Glucose - pharmacology ; Human health and pathology ; In Vitro Techniques ; Life Sciences ; Male ; Pectins - pharmacology ; Peptide Fragments - metabolism ; Rats ; Rats, Wistar ; Vertebrates: digestive system
É parte de: Journal of endocrinology, 1995-06, Vol.145 (3), p.521-526
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Glucagon-like peptide-1 (GLP-1) is released from endocrine cells of the distal part of the gut after ingestion of a meal. GLP-1 secretion is, in part, under the control of hormonal and/or neural mechanisms. However, stimulation of the colonic L cells may also occur directly by the luminal contents. This was examined in the present study, using an isolated vascularly perfused rat colon. GLP-1 immunoreactivity was measured in the portal effluent after luminal infusion of a variety of compounds which are found in colonic contents (nutrients, fibers, bile acids, short-chain fatty acids (SCFAs)). Oleic acid (100 mm) or a mixture of amino acids (total concentration 250 mm), or starch (0·5%, w/v) did not increase GLP-1 secretion over basal value. A pharmacological concentration of glucose (250 mm) elicited a marked release of GLP-1 which was maximal at the end of infusion (400% of basal), while 5 mm glucose was without effect on secretion. Pectin evoked a dose-dependent release of GLP-1 over the range 0·1–0·5% (w/v) with a maximal response at 360% of basal when 0·5% pectin was infused. Cellulose or gum arabic (0·5%) did not modify GLP-1 secretion. The SCFAs acetate, propionate or butyrate (5, 20 and 100 mm) did not induce a significant release of GLP-1. Among the four bile acids tested, namely taurocholate, cholate, deoxycholate and hyodeoxycholate, the last one was the most potent at eliciting a GLP-1 response with a maximal release at 300% and 400% of the basal value when 2 and 20 mm bile acid were administered respectively. In conclusion, some fibres and bile acids are capable of releasing colonic GLP-1 in rats and may contribute to the secretory activity of colonic L cells. Journal of Endocrinology (1995) 145, 521–526
Editor: Colchester: BioScientifica
Idioma: Inglês

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Luminal glucagon-like peptide-1(7–36) amide-releasing factors in the isolated vascularly perfused rat colon

PLAISANCIE, P ; DUMOULIN, V ; CHAYVIALLE, J.-A ; CUBER, J.-C

Colchester: BioScientifica

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