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Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

Shi, Ting ; Denouel, Angeline ; Tietjen, Anna K ; Campbell, Iain ; Moran, Emily ; Li, Xue ; Campbell, Harry ; Demont, Clarisse ; Nyawanda, Bryan O ; Chu, Helen Y ; Stoszek, Sonia K ; Krishnan, Anand ; Openshaw, Peter ; Falsey, Ann R ; Nair, Harish

The Journal of infectious diseases, 2020-10, Vol.222 (Supplement_7), p.S577-S583 [Periódico revisado por pares]

US: Oxford University Press

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Título:
Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis
Autor: Shi, Ting ; Denouel, Angeline ; Tietjen, Anna K ; Campbell, Iain ; Moran, Emily ; Li, Xue ; Campbell, Harry ; Demont, Clarisse ; Nyawanda, Bryan O ; Chu, Helen Y ; Stoszek, Sonia K ; Krishnan, Anand ; Openshaw, Peter ; Falsey, Ann R ; Nair, Harish
Assuntos: Aged ; Aged, 80 and over ; Cost of Illness ; Databases, Factual ; Developed Countries ; Developing countries ; Fatalities ; Global Burden of Disease ; Global Health ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Incidence ; LDCs ; Meta-analysis ; Older people ; Population studies ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus, Human ; Respiratory tract infection ; Systematic review
É parte de: The Journal of infectious diseases, 2020-10, Vol.222 (Supplement_7), p.S577-S583
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Abstract Respiratory syncytial virus–associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million–6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000–459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000–614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000–50 000) related to RSV-ARI globally. The hospital admission rate and hCFR were higher for those aged ≥65 years than for those aged 50–64 years. The disease burden of RSV-ARI among older adults is substantial, with limited data from developing countries. Appropriate prevention and management strategies are needed to reduce this burden.
Editor: US: Oxford University Press
Idioma: Inglês

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Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

Shi, Ting ; Denouel, Angeline ; Tietjen, Anna K ; Campbell, Iain ; Moran, Emily ; Li, Xue ; Campbell, Harry ; Demont, Clarisse ; Nyawanda, Bryan O ; Chu, Helen Y ; Stoszek, Sonia K ; Krishnan, Anand ; Openshaw, Peter ; Falsey, Ann R ; Nair, Harish

US: Oxford University Press

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