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Isolation of the Gene and Hypothalamic cDNA for the Common Precursor of Gonadotropin-Releasing Hormone and Prolactin Release-Inhibiting Factor in Human and Rat

Adelman, John P. ; Mason, Anthony J. ; Hayflick, Joel S. ; Seeburg, Peter H.

Proc. Natl. Acad. Sci. U.S.A.; (United States), 1986-01, Vol.83 (1), p.179-183 [Periódico revisado por pares]

Washington, DC: National Academy of Sciences of the United States of America

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Título:
Isolation of the Gene and Hypothalamic cDNA for the Common Precursor of Gonadotropin-Releasing Hormone and Prolactin Release-Inhibiting Factor in Human and Rat
Autor: Adelman, John P. ; Mason, Anthony J. ; Hayflick, Joel S. ; Seeburg, Peter H.
Assuntos: 550201 - Biochemistry- Tracer Techniques ; Amino acids ; ANIMALS ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMISTRY ; Biological and medical sciences ; BODY ; BRAIN ; CENTRAL NERVOUS SYSTEM ; CHEMISTRY ; CLONING ; Complementary DNA ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA - genetics ; DNA - isolation & purification ; DNA SEQUENCING ; DNA, Recombinant ; DNA-CLONING ; ELECTROPHORESIS ; Exons ; Female ; Fundamental and applied biological sciences. Psychology ; Generally accepted auditing standards ; Genes. Genome ; GENETIC ENGINEERING ; Gonadotropin-Releasing Hormone - genetics ; GONADOTROPINS ; HORMONES ; Humans ; HYPOTHALAMUS ; Hypothalamus - analysis ; ISOTOPES ; LH-RH ; LIBERINS ; LIGHT NUCLEI ; MAMMALS ; MAN ; MESSENGER-RNA ; Molecular and cellular biology ; Molecular genetics ; NERVOUS SYSTEM ; NUCLEI ; Nucleic Acid Hybridization ; NUCLEIC ACIDS ; Nucleotides ; ODD-ODD NUCLEI ; ORGANIC COMPOUNDS ; ORGANS ; PEPTIDE HORMONES ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; PITUITARY HORMONES ; Placenta - analysis ; Pregnancy ; PRIMATES ; Prolactin Release-Inhibiting Factors - genetics ; Protein precursors ; Protein Precursors - genetics ; RADIOISOTOPES ; RATS ; RECOMBINANT DNA ; RNA ; RNA, Messenger - genetics ; RODENTS ; Species Specificity ; STRUCTURAL CHEMICAL ANALYSIS ; VERTEBRATES
É parte de: Proc. Natl. Acad. Sci. U.S.A.; (United States), 1986-01, Vol.83 (1), p.179-183
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone (Gn-RH) and prolacting release-inhibiting factor (PIF) were isolated from libraries derived from human and rat hypothalamic mRNA. Nucleotide sequence analyses predict precursor proteins of 92 amino acids for both species and show identity between the human placental and human hypothalamic precursor proteins. Whereas the Gn-RH peptide structure is completely conserved in human and rat, the PIF domain of the precursor displays 70% interspecies homology. Genomic analyses revealed the presence of a single Gn-RH-PIF gene in human and rat containing sequences corresponding to the cDNA distributed across four exons.
Editor: Washington, DC: National Academy of Sciences of the United States of America
Idioma: Inglês

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Isolation of the Gene and Hypothalamic cDNA for the Common Precursor of Gonadotropin-Releasing Hormone and Prolactin Release-Inhibiting Factor in Human and Rat

Adelman, John P. ; Mason, Anthony J. ; Hayflick, Joel S. ; Seeburg, Peter H.

Washington, DC: National Academy of Sciences of the United States of America

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