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Complexation of 5-Fluorouracil with β-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug

Cabral, Ana ; Fernandes, Ana ; Joaquim, Neuza ; Veiga, Francisco ; Sofio, Sara ; Paiva, Isabel ; Esteso, Miguel ; Rodrigo, M. ; Valente, Artur ; Ribeiro, Ana

Toxics (Basel), 2022-06, Vol.10 (6), p.300 [Periódico revisado por pares]

Basel: MDPI AG

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Título:
Complexation of 5-Fluorouracil with β-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug
Autor: Cabral, Ana ; Fernandes, Ana ; Joaquim, Neuza ; Veiga, Francisco ; Sofio, Sara ; Paiva, Isabel ; Esteso, Miguel ; Rodrigo, M. ; Valente, Artur ; Ribeiro, Ana
Assuntos: 5-Fluorouracil ; Aqueous solutions ; Bioavailability ; Complex formation ; complexation ; Cyclodextrin ; Cyclodextrins ; Diffusion ; diffusion coefficients ; Drug delivery systems ; Drug dosages ; Encapsulation ; Pollutant removal ; Sodium ; Sodium dodecyl sulfate ; sodium dodecyl sulphate ; Sodium lauryl sulfate ; β-cyclodextrin
É parte de: Toxics (Basel), 2022-06, Vol.10 (6), p.300
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The formation of complexes of the drug 5-fluorouracil (5-FU) with β-cyclodextrin (β-CD) and sodium dodecyl sulphate (SDS) was studied through experimental measurements of the ternary mutual diffusion coefficients (D11, D22, D12, and D21) for the systems {5-FU (component 1) + β-CD (component 2) + water} and {5-FU (component 1) + SDS (component 2) + water} at 298.15 K and at concentrations up to 0.05 mol dm−3 by using the Taylor dispersion method, with the objective of removing this polluting drug from the residual systems in which it was present. The results found showed that a coupled diffusion of 5-FU occurred with both β-CD and SDS, as indicated by the nonzero values of the cross-diffusion coefficients, D12 and D21, as a consequence of the complex formation between 5-FU and the β-CD or SDS species. That is, 5-FU was solubilized (encapsulated) by both carriers, although to a greater extent with SDS (K = 20.0 (±0.5) mol−1 dm3) than with β-CD (K = 10.0 (±0.5) mol−1 dm3). Values of 0.107 and 0.190 were determined for the maximum fraction of 5-FU solubilized with β-CD and SDS (at concentrations above its CMC), respectively. This meant that SDS was more efficient at encapsulating and thus removing the 5-FU drug.
Editor: Basel: MDPI AG
Idioma: Inglês

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Complexation of 5-Fluorouracil with β-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug

Cabral, Ana ; Fernandes, Ana ; Joaquim, Neuza ; Veiga, Francisco ; Sofio, Sara ; Paiva, Isabel ; Esteso, Miguel ; Rodrigo, M. ; Valente, Artur ; Ribeiro, Ana

Basel: MDPI AG

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