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Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity

Lynch, Cheryl S ; Story, Allen J

Physiology & behavior, 2000-06, Vol.69 (4), p.445-453 [Periódico revisado por pares]

Cambridge: Elsevier Inc

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Título:
Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity
Autor: Lynch, Cheryl S ; Story, Allen J
Assuntos: Amygdala ; Amygdala - drug effects ; Amygdala - metabolism ; Anabolic Agents - pharmacology ; Animals ; Athlete ; Behavioral psychophysiology ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Castration ; Cell Count - drug effects ; Dihydrotestosterone - metabolism ; Dihydrotestoterone ; Estrogen ; Estrogens - metabolism ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Hypothalamus ; Image Processing, Computer-Assisted ; Immunocytochemistry ; Immunohistochemistry ; Male ; Nandrolone - analogs & derivatives ; Nandrolone - pharmacology ; Nandrolone Decanoate ; Preoptic Area - drug effects ; Preoptic Area - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans ; Receptors, Androgen - metabolism ; Steroid abuse ; Steroid receptor ; Testosterone ; Testosterone - analogs & derivatives ; Testosterone - pharmacology ; Up-Regulation - drug effects ; Ventromedial Hypothalamic Nucleus - drug effects ; Ventromedial Hypothalamic Nucleus - metabolism
É parte de: Physiology & behavior, 2000-06, Vol.69 (4), p.445-453
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Androgen-receptor upregulation that occurs with androgenic-anabolic steroid (AAS) administration may be mediated by AAS metabolites, dihydrotestosterone (DHT), and estrogen. Castrated and intact male rats received 14 s.c. daily injections of AAS (2 mg/kg testosterone cypionate, 2 mg/kg nandrolone decanoate, and 1 mg/kg boldenone undecylenate in sesame oil vehicle), DHT (5 mg/kg dihydrotestosterone), EB (5 mg/kg estradiol benzoate), or sesame oil vehicle. Approximately 18–24 h after the fourteenth injection, brain tissues were removed and processed immunocytochemically using the PG-21 androgen-receptor antibody. As reported before, castration eliminated AR-ir (androgen-receptor immunoreactivity) and AAS upregulated AR-ir in the ventromedial hypothalamus (VMHVL), medial amygdala (MePV), and medial preoptic area (MPOM). When compared to AAS, DHT fully upregulated AR-ir in the VM VL and MPOM and partially upregulated AR-ir in the MePV. EB treatment partially upregulated AR-ir in the VMHVL and MePV, but not in the MPOM of castrated rats. Because AR-ir in the MPOM was consistently upregulated by DHT or AAS, and not EB, androgen-receptor availability in this region may be mediated specifically via androgen receptors.
Editor: Cambridge: Elsevier Inc
Idioma: Inglês

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Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity

Lynch, Cheryl S ; Story, Allen J

Cambridge: Elsevier Inc

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