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Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

Petschow, Bryon W ; Blikslager, Anthony T ; Weaver, Eric M ; Campbell, Joy M ; Polo, Javier ; Shaw, Audrey L ; Burnett, Bruce P ; Klein, Gerald L ; Rhoads, J Marc

World journal of gastroenterology : WJG, 2014-09, Vol.20 (33), p.11713-11726

United States: Baishideng Publishing Group Inc

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Título:
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy
Autor: Petschow, Bryon W ; Blikslager, Anthony T ; Weaver, Eric M ; Campbell, Joy M ; Polo, Javier ; Shaw, Audrey L ; Burnett, Bruce P ; Klein, Gerald L ; Rhoads, J Marc
Assuntos: Administration, Oral ; Animals ; Dietary Proteins - administration & dosage ; Dietary Proteins - adverse effects ; Gut ; Humans ; Immunoglobulins ; Immunoglobulins - administration & dosage ; Immunoglobulins - adverse effects ; Inflam-mation ; Inflammation Mediators - metabolism ; Intestinal Absorption ; Intestinal Diseases - diagnosis ; Intestinal Diseases - immunology ; Intestinal Diseases - metabolism ; Intestinal Diseases - microbiology ; Intestinal Diseases - physiopathology ; Intestinal Diseases - therapy ; Intestines - immunology ; Intestines - metabolism ; Intestines - microbiology ; Intestines - physiopathology ; Microbiota ; Nutritional Status ; Nutritional Support - adverse effects ; Nutritional Support - methods ; Permeability ; Plasma ; proteins ; Review ; Treatment Outcome
É parte de: World journal of gastroenterology : WJG, 2014-09, Vol.20 (33), p.11713-11726
Notas: Bryon W Petschow;Anthony T Blikslager;Eric M Weaver;Joy M Campbell;Javier Polo;Audrey L Shaw;Bruce P Burnett;Gerald L Klein;J Marc Rhoads;Entera Health, Inc., NC 27518, United States;College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, United States;APC, Inc., Ankeny, IA 50021, United States;APC Europe, S.A., Barcelona, E-08403, Spain;University of Texas Health Sciences Center, Houston, TX 77030, United States
Correspondence to: Bryon W Petschow, PhD, Entera Health, Inc., 2000 Regency Parkway, Suite 255 Cary, NC 27518, United States. bryon.petschow@enterahealth.com
Telephone: +1-919-6160014 Fax: +1-919-3191437
Author contributions: Petschow BW, Weaver EM and Rhoads JM wrote the paper and made critical contributions to its intellectual content; Blikslager AT, Campbell JM, Polo J, Shaw AL and Burnett BP reviewed and edited the paper; Klein GL and Rhoads JM had primary responsibility for the final content.
Descrição: The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy.
Editor: United States: Baishideng Publishing Group Inc
Idioma: Inglês

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Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

Petschow, Bryon W ; Blikslager, Anthony T ; Weaver, Eric M ; Campbell, Joy M ; Polo, Javier ; Shaw, Audrey L ; Burnett, Bruce P ; Klein, Gerald L ; Rhoads, J Marc

United States: Baishideng Publishing Group Inc

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