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Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria

Yan, Sheng Tao ; Sun, Li Chao ; Jia, Hong Bing ; Gao, Wen ; Yang, Jian Ping ; Zhang, Guo Qiang

The American journal of emergency medicine, 2017-04, Vol.35 (4), p.579-583 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria
Autor: Yan, Sheng Tao ; Sun, Li Chao ; Jia, Hong Bing ; Gao, Wen ; Yang, Jian Ping ; Zhang, Guo Qiang
Assuntos: Acinetobacter baumannii ; Acinetobacter Infections - blood ; Acinetobacter Infections - microbiology ; Aged ; Aged, 80 and over ; Arthritis ; Bacteremia - blood ; Bacteremia - microbiology ; Bacteria ; Bacterial infections ; Bacterial species ; Biomarkers ; Biomarkers - blood ; Burkholderia ; Burkholderia cepacia ; Burkholderia Infections - blood ; Burkholderia Infections - microbiology ; Calcitonin - blood ; Catheter-Related Infections - blood ; Catheter-Related Infections - microbiology ; Cutoffs ; Disease ; Emergency ; Emergency Service, Hospital ; Endocarditis, Bacterial - blood ; Endocarditis, Bacterial - microbiology ; Enterococcus faecalis ; Enterococcus faecium ; Escherichia coli ; Escherichia coli Infections - blood ; Escherichia coli Infections - microbiology ; Family medical history ; Female ; Gram-negative bacteria ; Gram-Negative Bacterial Infections - blood ; Gram-Negative Bacterial Infections - microbiology ; Gram-positive bacteria ; Gram-Positive Bacterial Infections - blood ; Gram-Positive Bacterial Infections - microbiology ; Humans ; Infection sites ; Infections ; Intensive care ; Intensive Care Units ; Klebsiella ; Klebsiella Infections - blood ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae ; Laboratories ; Lung cancer ; Lupus ; Male ; Medical instruments ; Microorganisms ; Middle Aged ; Multiple sclerosis ; Pathogens ; Patients ; Pneumonia ; Pneumonia, Bacterial - blood ; Pneumonia, Bacterial - microbiology ; Positive blood culture ; Procalcitonin ; Retrospective Studies ; Sepsis ; Staphylococcal Infections - blood ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus epidermidis ; Staphylococcus haemolyticus ; Staphylococcus hominis ; Thyroid cancer ; Urinary tract ; Urinary Tract Infections - blood ; Urinary Tract Infections - microbiology
É parte de: The American journal of emergency medicine, 2017-04, Vol.35 (4), p.579-583
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Objective The aim of this study was to evaluate procalcitonin (PCT) diagnostic accuracy in discriminating gram-negative (GN) from gram-positive (GP) bloodstream infections and determining the relationship between PCT levels, infection sites, and pathogen types. Methods Clinical and laboratory data were collected from patients with blood culture (BC)-positive sepsis between January 2014 and December 2015. PCT levels at different infection sites were compared, as was the presence of GN and GP bloodstream infection. A receiver operating characteristic (ROC) curve was generated to assess diagnostic accuracy. Results Of the 486 monomicrobial BCs, 254 (52.26%) were positive for GN bacteria (GNB), and 202 (42.18%) for GP bacteria (GPB). Median PCT levels were higher in BCs positive for GN (2.42 ng/ml, IQR: 0.38–15.52) than in those positive for GPB (0.49 ng/ml, IQR: 0.13–5.89) ( P < 0.001). In the ROC analysis to differentiate between GNB and GPB, the area under the curve was 0.628 (95% CI: 0.576–0.679). When the cutoffs for PCT were 10.335 and 15.000 ng/ml, the specificity of GNB infection was 80.2% and 84.2%, respectively. PCT levels caused by GNB differed between Escherichia coli and Acinetobacter baumanni / Burkholderia cepacia , Klebsiella pneumonia and Acinetobacter baumanni . PCT levels caused by GPB differed between Staphylococcus epidermidis / Staphylococcus aureus and Staphylococcus hominis / Staphylococcus haemolyticus , Enterococcus faecium and Enterococcus faecalis / S.hominis / S. haemolyticus . Among patients with known infection sites, there were statistical differences in PCT levels between abdominal infection and pneumonia/infective endocarditis, urinary tract infection and pneumonia/catheter-related infection/infective endocarditis. Conclusion PCT can distinguish between GNB and GPB infection, as well as between different bacterial species and infection sites.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria

Yan, Sheng Tao ; Sun, Li Chao ; Jia, Hong Bing ; Gao, Wen ; Yang, Jian Ping ; Zhang, Guo Qiang

United States: Elsevier Inc

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