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Reproducibility of preclinical animal research improves with heterogeneity of study samples

Voelkl, Bernhard ; Vogt, Lucile ; Sena, Emily S ; Würbel, Hanno Wagenmakers, Eric-Jan

PLoS biology, 2018-02, Vol.16 (2), p.e2003693-e2003693 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Reproducibility of preclinical animal research improves with heterogeneity of study samples
Autor: Voelkl, Bernhard ; Vogt, Lucile ; Sena, Emily S ; Würbel, Hanno
Wagenmakers, Eric-Jan
Assuntos: Animal Experimentation - standards ; Animal models ; Animal sciences ; Animals ; Bias ; Breast cancer ; Cerebral infarction ; Computer simulation ; Disease Models, Animal ; Food ; Heart attacks ; Laboratories - organization & administration ; Laboratory animals ; Medicine and Health Sciences ; Meta ; Meta-analysis ; Myocardial infarction ; Physical Sciences ; Probability ; Reproducibility ; Reproducibility of Results ; Research and Analysis Methods ; Research Design - standards ; Sample Size ; Standardization ; Stem cells ; Studies ; Supervision ; Systematic review ; Validity ; Zoology
É parte de: PLoS biology, 2018-02, Vol.16 (2), p.e2003693-e2003693
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors have declared that no competing interests exist.
Descrição: Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast cancer, we compared the accuracy of effect size estimates between single-laboratory and multi-laboratory study designs. Single-laboratory studies generally failed to predict effect size accurately, and larger sample sizes rendered effect size estimates even less accurate. By contrast, multi-laboratory designs including as few as 2 to 4 laboratories increased coverage probability by up to 42 percentage points without a need for larger sample sizes. These findings demonstrate that within-study standardization is a major cause of poor reproducibility. More representative study samples are required to improve the external validity and reproducibility of preclinical animal research and to prevent wasting animals and resources for inconclusive research.
Editor: United States: Public Library of Science
Idioma: Inglês

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Reproducibility of preclinical animal research improves with heterogeneity of study samples

Voelkl, Bernhard ; Vogt, Lucile ; Sena, Emily S ; Würbel, Hanno Wagenmakers, Eric-Jan

United States: Public Library of Science

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