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Laser-Induced Porcine Model of Experimental Retinal Vein Occlusion: An Optimized Reproducible Approach

Mæng, Mads Odgaard ; Roshanth, Nirrooja ; Kruse, Anders ; Nielsen, Jonas Ellegaard ; Kjærgaard, Benedict ; Honoré, Bent ; Vorum, Henrik ; Cehofski, Lasse Jørgensen

Medicina (Kaunas, Lithuania), 2023-01, Vol.59 (2), p.243 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Laser-Induced Porcine Model of Experimental Retinal Vein Occlusion: An Optimized Reproducible Approach
Autor: Mæng, Mads Odgaard ; Roshanth, Nirrooja ; Kruse, Anders ; Nielsen, Jonas Ellegaard ; Kjærgaard, Benedict ; Honoré, Bent ; Vorum, Henrik ; Cehofski, Lasse Jørgensen
Assuntos: animal model ; Animal models in research ; Animals ; Catheters ; Cornea ; Development and progression ; Diabetic retinopathy ; Edema ; Glaucoma ; Hogs ; Lasers ; mass spectrometry ; Medical imaging ; Methods ; Optic nerve ; Optics ; Patients ; proteome ; Proteomics ; Reproducibility of Results ; Retina ; Retinal diseases ; retinal vein occlusion ; Retinal Vein Occlusion - complications ; Retinal Vein Occlusion - drug therapy ; Review ; Swine ; Tomography ; Tomography, Optical Coherence ; Vascular endothelial growth factor
É parte de: Medicina (Kaunas, Lithuania), 2023-01, Vol.59 (2), p.243
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Retinal vein occlusion (RVO) is a frequent visually disabling condition. The management of RVO continues to challenge clinicians. Macular edema secondary to RVO is often recurrent, and patients typically require intravitreal injections for several years. Understanding molecular mechanisms in RVO is a key element in improving the treatment of the condition. Studying the molecular mechanisms in RVO at the retinal level is possible using animal models of experimental RVO. Most studies of experimental RVO have been sporadic, using only a few animals per experiment. Here, we report on 10 years of experience of the use of argon laser-induced experimental RVO in 108 porcine eyes from 65 animals, including 65 eyes with experimental branch retinal vein occlusion (BRVO) and 43 eyes with experimental central retinal vein occlusion (CRVO). Reproducibility and methods for evaluating and controlling ischemia in experimental RVO are reviewed. Methods for studying protein changes in RVO are discussed in detail, including proteomic analysis, Western blotting, and immunohistochemistry. Experimental RVO has brought significant insights into molecular changes in RVO. Testing intravitreal interventions in experimental RVO may be a significant step in developing personalized therapeutic approaches for patients with RVO.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Laser-Induced Porcine Model of Experimental Retinal Vein Occlusion: An Optimized Reproducible Approach

Mæng, Mads Odgaard ; Roshanth, Nirrooja ; Kruse, Anders ; Nielsen, Jonas Ellegaard ; Kjærgaard, Benedict ; Honoré, Bent ; Vorum, Henrik ; Cehofski, Lasse Jørgensen

Switzerland: MDPI AG

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