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Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques

Miller, Karla L. ; McNab, Jennifer A. ; Jbabdi, Saad ; Douaud, Gwenaëlle

NeuroImage (Orlando, Fla.), 2012-02, Vol.59 (3), p.2284-2297 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
Autor: Miller, Karla L. ; McNab, Jennifer A. ; Jbabdi, Saad ; Douaud, Gwenaëlle
Assuntos: Algorithms ; Brain ; Brain - anatomy & histology ; Buffers ; Cadaver ; Corpus Callosum - anatomy & histology ; Data Interpretation, Statistical ; Diffusion ; Diffusion Tensor Imaging - methods ; DTI ; Echo-Planar Imaging - methods ; Efficiency ; Gyrus Cinguli - anatomy & histology ; Humans ; Image Processing, Computer-Assisted - methods ; Methods ; Models, Statistical ; Nerve Fibers - physiology ; Neural Pathways - anatomy & histology ; Optimization ; Post mortem ; Pyramidal Tracts - anatomy & histology ; Quality Control ; Reproducibility of Results ; Scanners ; Signal-To-Noise Ratio ; Steady-state free precession ; Studies ; Tissue Fixation ; Tractography
É parte de: NeuroImage (Orlando, Fla.), 2012-02, Vol.59 (3), p.2284-2297
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SourceType-Scholarly Journals-1
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Descrição: Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. ► Comparison of DW-SE and DW-SSFP for post-mortem imaging on clinical scanners. ► Optimization of protocols predicts 50-130% higher SNR efficiency in DW-SSFP. ► Comparison of tractography 6- and 12-hour DW-SE and DW-SSFP scans. ► Lower uncertainty on fibre direction in DW-SSFP produces superior tractography. ► Crossing fibres can be estimated from 12-hour DW-SSFP data.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques

Miller, Karla L. ; McNab, Jennifer A. ; Jbabdi, Saad ; Douaud, Gwenaëlle

United States: Elsevier Inc

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