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Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation

Cardoso, C. R. ; Teixeira, G. ; Provinciatto, P. R. ; Godoi, D. F. ; Ferreira, B. R. ; Milanezi, C. M. ; Ferraz, D. B. ; Rossi, M. A. ; Cunha, F. Q. ; Silva, J. S.

Clinical and experimental allergy, 2008-02, Vol.38 (2), p.338-349 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation
Autor: Cardoso, C. R. ; Teixeira, G. ; Provinciatto, P. R. ; Godoi, D. F. ; Ferreira, B. R. ; Milanezi, C. M. ; Ferraz, D. B. ; Rossi, M. A. ; Cunha, F. Q. ; Silva, J. S.
Assuntos: Allergic diseases ; animal model ; Animals ; Arachis - chemistry ; Arachis - immunology ; Biological and medical sciences ; Colitis - genetics ; Colitis - immunology ; Colitis - pathology ; Cytokines - metabolism ; Digestive allergic diseases ; Disease Models, Animal ; food allergy ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; GATA3 Transcription Factor - metabolism ; Gene Expression ; Immunity, Mucosal ; Immunoglobulin E - blood ; Immunoglobulin G - blood ; Immunoglobulins - metabolism ; Immunopathology ; intestinal inflammation ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Leukocytes - immunology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; mucosal immune response ; peanut ; Peanut Hypersensitivity - complications ; Peyer's Patches - immunology ; Plant Extracts - chemistry ; Plant Extracts - immunology ; Th2 Cells - immunology ; Weight Loss
É parte de: Clinical and experimental allergy, 2008-02, Vol.38 (2), p.338-349
Notas: ark:/67375/WNG-FHPR2Z17-Z
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Descrição: Summary Background Hypersensitivity or uncontrolled responses against dietary antigens can lead to inflammatory disorders like food allergy and current models reflect a variety of causes but do not reveal the detailed modulation of gut immunity in response to food antigens after breakdown in mucosal tolerance. Objective To develop and characterize a murine model for food‐induced intestinal inflammation and to demonstrate the modulation of gut immune response by dietary allergenic antigens. Methods C57BL/6 mice were sensitized with peanut proteins, challenged with peanut seeds and their sera and gut segments were collected for subsequent analyses. Results Sensitization and challenged with peanut seeds led to alterations in gut architecture with inflammatory response characterized by oedema in lamina propria and cell infiltrate composed mainly by eosinophils, mast cells, phagocytes, natural killer and plasma cells, together with low percentage of γδ+ and CD4+CD25+Foxp3+ cells in Peyer's patches. These animals also presented high levels of specific IgE and IgG1 in sera and modulation of mucosal immunity was mediated by increased expression of GATA‐3, IL‐4, IL‐13 and TNF‐α in contrast to low IFN‐γ in the gut. Conclusion A murine model for food‐induced intestinal inflammation was characterized in which modulation of gut immunity occurs by peanut antigens in consequence of T‐helper type 2 (Th2) allergic response and failure of regulatory mechanisms necessary for mucosa homeostasis, resembling food allergy. This work shed some light on the understanding of the pathogenesis of gastrointestinal disorders and intolerance in the gut and supports the development of therapies for food‐related enteropathies like food allergy, focusing on gut‐specific immune response.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation

Cardoso, C. R. ; Teixeira, G. ; Provinciatto, P. R. ; Godoi, D. F. ; Ferreira, B. R. ; Milanezi, C. M. ; Ferraz, D. B. ; Rossi, M. A. ; Cunha, F. Q. ; Silva, J. S.

Oxford, UK: Blackwell Publishing Ltd

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