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Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics

Antunes, L. Caetano M ; Arena, Ellen T ; Menendez, Alfredo ; Han, Jun ; Ferreira, Rosana B.R ; Buckner, Michelle M.C ; Lolić, Petra ; Madilao, Lufiani L ; Bohlmann, Jörg ; Borchers, Christoph H ; Finlay, B. Brett Bäumler, A. J.

Infection and Immunity, 2011-04, Vol.79 (4), p.1759-1769 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics
Autor: Antunes, L. Caetano M ; Arena, Ellen T ; Menendez, Alfredo ; Han, Jun ; Ferreira, Rosana B.R ; Buckner, Michelle M.C ; Lolić, Petra ; Madilao, Lufiani L ; Bohlmann, Jörg ; Borchers, Christoph H ; Finlay, B. Brett
Bäumler, A. J.
Assuntos: Animals ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; biochemical pathways ; Biological and medical sciences ; chemical composition ; Enzyme-Linked Immunosorbent Assay ; Female ; Fourier Analysis ; Fundamental and applied biological sciences. Psychology ; hormone metabolism ; Host Response and Inflammation ; Host-Parasite Interactions - physiology ; host-pathogen relationships ; hosts ; Human bacterial diseases ; immune response ; Infectious diseases ; Male ; Mass Spectrometry ; Medical sciences ; metabolomics ; Metabolomics - methods ; Mice ; Mice, Inbred C57BL ; Microbiology ; mutants ; new methods ; pathogens ; proteomics ; Reverse Transcriptase Polymerase Chain Reaction ; Salmonella enterica subsp. enterica serovar Typhimurium ; Salmonella Infections, Animal - metabolism ; salmonellosis ; transcriptomics
É parte de: Infection and Immunity, 2011-04, Vol.79 (4), p.1759-1769
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Editor: A. J. Bäumler
Descrição: The interplay between pathogens and their hosts has been studied for decades using targeted approaches, such as the analysis of mutants and host immunological responses. Although much has been learned from such studies, they focus on individual pathways and fail to reveal the global effects of infection on the host. To alleviate this issue, high-throughput methods, such as transcriptomics and proteomics, have been used to study host-pathogen interactions. Recently, metabolomics was established as a new method to study changes in the biochemical composition of host tissues. We report a metabolomic study of Salmonella enterica serovar Typhimurium infection. Our results revealed that dozens of host metabolic pathways are affected by Salmonella in a murine infection model. In particular, multiple host hormone pathways are disrupted. Our results identify unappreciated effects of infection on host metabolism and shed light on mechanisms used by Salmonella to cause disease and by the host to counter infection.
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics

Antunes, L. Caetano M ; Arena, Ellen T ; Menendez, Alfredo ; Han, Jun ; Ferreira, Rosana B.R ; Buckner, Michelle M.C ; Lolić, Petra ; Madilao, Lufiani L ; Bohlmann, Jörg ; Borchers, Christoph H ; Finlay, B. Brett Bäumler, A. J.

Washington, DC: American Society for Microbiology

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