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Natural and human-driven selection of a single non-coding body size variant in ancient and modern canids

Plassais, Jocelyn ; vonHoldt, Bridgett M. ; Parker, Heidi G. ; Carmagnini, Alberto ; Dubos, Nicolas ; Papa, Ilenia ; Bevant, Kevin ; Derrien, Thomas ; Hennelly, Lauren M. ; Whitaker, D. Thad ; Harris, Alex C. ; Hogan, Andrew N. ; Huson, Heather J. ; Zaibert, Victor F. ; Linderholm, Anna ; Haile, James ; Fest, Thierry ; Habib, Bilal ; Sacks, Benjamin N. ; Benecke, Norbert ; Outram, Alan K. ; Sablin, Mikhail V. ; Germonpré, Mietje ; Larson, Greger ; Frantz, Laurent ; Ostrander, Elaine A.

Current biology, 2022-02, Vol.32 (4), p.889-897.e9 [Periódico revisado por pares]

England: Elsevier Inc

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  • Título:
    Natural and human-driven selection of a single non-coding body size variant in ancient and modern canids
  • Autor: Plassais, Jocelyn ; vonHoldt, Bridgett M. ; Parker, Heidi G. ; Carmagnini, Alberto ; Dubos, Nicolas ; Papa, Ilenia ; Bevant, Kevin ; Derrien, Thomas ; Hennelly, Lauren M. ; Whitaker, D. Thad ; Harris, Alex C. ; Hogan, Andrew N. ; Huson, Heather J. ; Zaibert, Victor F. ; Linderholm, Anna ; Haile, James ; Fest, Thierry ; Habib, Bilal ; Sacks, Benjamin N. ; Benecke, Norbert ; Outram, Alan K. ; Sablin, Mikhail V. ; Germonpré, Mietje ; Larson, Greger ; Frantz, Laurent ; Ostrander, Elaine A.
  • Assuntos: Alleles ; ancient DNA ; Animal genetics ; Animals ; antisense lncRNA ; Biodiversity ; body size ; Body Size - genetics ; Breeding ; canid evolution ; Canidae - genetics ; canine ; dog ; domestication ; Genetics ; Humans ; IGF1 ; Life Sciences ; long non-coding RNA ; Populations and Evolution ; wolf ; Wolves - genetics
  • É parte de: Current biology, 2022-02, Vol.32 (4), p.889-897.e9
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    PMCID: PMC8891063
    Author contributions: J.P. and E.A.O. developed, planned the research and wrote the manuscript. J.P conducted the experiments, performed data analyses, and created the figures. B.M.V, H.G.P, A.C, N.D, T.D, L.M.H, M.S, M.G, L.F. performed statistical analyses. B.M.V, H.G.P, I.P, K.B, L.M.H, D.T.W, A.C.H, A.N.H, H.H, V.F.Z, A.L, J.H, T.F, B.H, B.N.S, N.B, A.K.O, M.V.S, M.G, G.L, and L.F. assisted in sample and data acquisition. All authors revised and edited the final manuscript and figures.
  • Descrição: Domestic dogs (Canis lupus familiaris) are the most variable-sized mammalian species on Earth, displaying a 40-fold size difference between breeds.1 Although dogs of variable size are found in the archeological record,2–4 the most dramatic shifts in body size are the result of selection over the last two centuries, as dog breeders selected and propagated phenotypic extremes within closed breeding populations.5 Analyses of over 200 domestic breeds have identified approximately 20 body size genes regulating insulin processing, fatty acid metabolism, TGFβ signaling, and skeletal formation.6–10 Of these, insulin-like growth factor 1 (IGF1) predominates, controlling approximately 15% of body size variation between breeds.8 The identification of a functional mutation associated with IGF1 has thus far proven elusive.6,10,11 Here, to identify and elucidate the role of an ancestral IGF1 allele in the propagation of modern canids, we analyzed 1,431 genome sequences from 13 species, including both ancient and modern canids, thus allowing us to define the evolutionary history of both ancestral and derived alleles at this locus. We identified a single variant in an antisense long non-coding RNA (IGF1-AS) that interacts with the IGF1 gene, creating a duplex. While the derived mutation predominates in both modern gray wolves and large domestic breeds, the ancestral allele, which predisposes to small size, was common in small-sized breeds and smaller wild canids. Our analyses demonstrate that this major regulator of canid body size nearly vanished in Pleistocene wolves, before its recent resurgence resulting from human-imposed selection for small-sized breed dogs. •An ancestral variant on IGF1 locus regulates body size in ancient and modern dogs•Variant alleles are associated with body size in dogs, wolves, and coyotes•The large body size-associated allele arose more than 53,000 years ago in wolves•Human selection for small size may have been a major force during domestication Plassais et al. assemble a catalog of thousands of genomes, inclusive of ancient and modern canids, in a search for genetic variants passed from ancient to modern dogs. They identify an ancient mutation at the IGF1 locus, which has been under human selection, that contributes to a significant portion of body size in modern dogs.
  • Editor: England: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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