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Downstream insulin-like growth factor
Pfäffle, Roland ; Kiess, Wieland ; Klammt, Jürgen
Endocrine development, 2012, Vol.23, p.42
[Periódico revisado por pares]
Switzerland
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Título:
Downstream insulin-like growth factor
Autor:
Pfäffle, Roland
;
Kiess, Wieland
;
Klammt, Jürgen
Assuntos:
Animals
;
Child
;
Female
;
Fetal Growth Retardation - blood
;
Fetal Growth Retardation - etiology
;
Fetal Growth Retardation - genetics
;
Humans
;
Infant, Newborn
;
Infant, Small for Gestational Age - blood
;
Infant, Small for Gestational Age - growth & development
;
Models, Biological
;
Pregnancy
;
Receptor, IGF Type 1 - genetics
;
Receptor, IGF Type 1 - physiology
;
Signal Transduction - genetics
;
Signal Transduction - physiology
;
Somatomedins - analysis
;
Somatomedins - genetics
;
Somatomedins - metabolism
É parte de:
Endocrine development, 2012, Vol.23, p.42
Descrição:
Until 10 years ago genetic defects that cause a child to be born small for gestational age (SGA) were poorly defined. With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic defects at the lower end of the GH-IGF-1 axis were identified as a monogenetic cause of intrauterine growth retardation. These patients failed to thrive despite normal IGF-1 serum concentrations thereby establishing a concept of IGF-1 resistance in these patients. The identification of additional patients along with functional, genetic and structural examinations of the different IGF-1R mutations have provided evidence for a variability of the pathogenic impact that mutations of the IGF-1R have on human longitudinal growth. However, the seemingly variable incidence of further clinical features such as developmental delay, suggest that at least some of the functions within the IGF-IGF-1R system are in part redundant. This redundancy may depend on the genetic background and environmental factors. At the lower end of the GHRH-IGF-1 axis, primary IGF-1 deficiency and IGF-1 resistance due to defects within the IGF-1 and IGF-1 receptor (IGF-1R) genes account for approximately 10-15% of all cases with intrauterine and postnatal growth retardation.
Editor:
Switzerland
Idioma:
Inglês
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