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A Snapshot on the Genomic Epidemiology of Turkey Reovirus Infections, Hungary

Gál, Bence ; Varga-Kugler, Renáta ; Ihász, Katalin ; Kaszab, Eszter ; Farkas, Szilvia ; Marton, Szilvia ; Martella, Vito ; Bányai, Krisztián

Animals (Basel), 2023-11, Vol.13 (22), p.3504 [Periódico revisado por pares]

MDPI AG

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  • Título:
    A Snapshot on the Genomic Epidemiology of Turkey Reovirus Infections, Hungary
  • Autor: Gál, Bence ; Varga-Kugler, Renáta ; Ihász, Katalin ; Kaszab, Eszter ; Farkas, Szilvia ; Marton, Szilvia ; Martella, Vito ; Bányai, Krisztián
  • Assuntos: Avian orthoreovirus ; Epidemiology ; Genes ; Genetic aspects ; Genomes ; Genomics ; Health aspects ; Infection ; interspecies transmission ; phylogenetic analysis ; Phylogeny ; Protein binding ; reassortment ; Spinareoviridae ; Turkeys ; whole-genome sequencing
  • É parte de: Animals (Basel), 2023-11, Vol.13 (22), p.3504
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Reovirus infections in turkeys are associated with arthritis and lameness. Viral genome sequence data are scarce, which makes an accurate description of the viral evolution and epidemiology difficult. In this study, we isolated and characterized turkey reoviruses from Hungary. The isolates were identified in 2016; these isolates were compared with earlier Hungarian turkey reovirus strains and turkey reoviruses isolated in the 2010s in the United States. Gene-wise sequence and phylogenetic analyses identified the cell-receptor binding protein and the main neutralization antigen, σC, to be the most conserved. The most genetically diverse gene was another surface antigen coding gene, μB. This gene was shown to undergo frequent reassortment among chicken and turkey origin reoviruses. Additional reassortment events were found primarily within members of the homologous turkey reovirus clade. Our data showed evidence for low variability among strains isolated from independent outbreaks, a finding that suggests a common source of turkey reoviruses in Hungarian turkey flocks. Given that commercial vaccines are not available, identification of the source of these founder virus strains would permit a more efficient prevention of disease outbreaks before young birds are settled to fattening facilities.
  • Editor: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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