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Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia

Price, Vera H. ; Roberts, Janet L. ; Hordinsky, Maria ; Olsen, Elise A. ; Savin, Ronald ; Bergfeld, Wilma ; Fiedler, Virginia ; Lucky, Anne ; Whiting, David A. ; Pappas, Frances ; Culbertson, Jennifer ; Kotey, Paul ; Meehan, Alan ; Waldstreicher, Joanne

Journal of the American Academy of Dermatology, 2000-11, Vol.43 (5), p.768-776 [Periódico revisado por pares]

New York, NY: Mosby, Inc

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Título:
Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia
Autor: Price, Vera H. ; Roberts, Janet L. ; Hordinsky, Maria ; Olsen, Elise A. ; Savin, Ronald ; Bergfeld, Wilma ; Fiedler, Virginia ; Lucky, Anne ; Whiting, David A. ; Pappas, Frances ; Culbertson, Jennifer ; Kotey, Paul ; Meehan, Alan ; Waldstreicher, Joanne
Assuntos: Administration, Oral ; Adult ; Alopecia - drug therapy ; Alopecia - pathology ; Biological and medical sciences ; Biopsy ; Disease Progression ; Double-Blind Method ; Enzyme Inhibitors - administration & dosage ; Enzyme Inhibitors - pharmacology ; Female ; Finasteride - administration & dosage ; Finasteride - pharmacology ; Humans ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postmenopause ; Scalp - pathology ; Skin, nail, hair, dermoskeleton ; Treatment Outcome
É parte de: Journal of the American Academy of Dermatology, 2000-11, Vol.43 (5), p.768-776
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
Descrição: Background: Finasteride, an inhibitor of type 2 5α-reductase, decreases serum and scalp dihydrotestosterone (DHT) by inhibiting conversion of testosterone to DHT and has been shown to be effective in men with androgenetic alopecia (AGA). The effects of finasteride in women with AGA have not been evaluated. Objective: The purpose of this study was to evaluate the efficacy of finasteride in postmenopausal women with AGA. Methods: In this 1-year, double-blind, placebo-controlled, randomized, multicenter trial, 137 postmenopausal women (41-60 years of age) with AGA received finasteride 1 mg/day or placebo. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, assessment of global photographs by a blinded expert panel, and histologic analysis of scalp biopsy specimens. Results: After 1 year of therapy, there was no significant difference in the change in hair count between the finasteride and placebo groups. Both treatment groups had significant decreases in hair count in the frontal/parietal (anterior/mid) scalp during the 1-year study period. Similarly, patient, investigator, and photographic assessments as well as scalp biopsy analysis did not demonstrate any improvement in slowing hair thinning, increasing hair growth, or improving the appearance of the hair in finasteride-treated subjects compared with the placebo group. Finasteride was generally well tolerated. Conclusion: In postmenopausal women with AGA, finasteride 1 mg/day taken for 12 months did not not increase hair growth or slow the progression of hair thinning. (J Am Acad Dermatol 2000;43:768-76.)
Editor: New York, NY: Mosby, Inc
Idioma: Inglês

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Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia

Price, Vera H. ; Roberts, Janet L. ; Hordinsky, Maria ; Olsen, Elise A. ; Savin, Ronald ; Bergfeld, Wilma ; Fiedler, Virginia ; Lucky, Anne ; Whiting, David A. ; Pappas, Frances ; Culbertson, Jennifer ; Kotey, Paul ; Meehan, Alan ; Waldstreicher, Joanne

New York, NY: Mosby, Inc

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