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Origin of oligodendrocytes in mammalian forebrains: a revised perspective

Naruse, Masae ; Ishizaki, Yasuki ; Ikenaka, Kazuhiro ; Tanaka, Aoi ; Hitoshi, Seiji

The journal of physiological sciences, 2017-01, Vol.67 (1), p.63-70 [Periódico revisado por pares]

Japan: Springer

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Título:
Origin of oligodendrocytes in mammalian forebrains: a revised perspective
Autor: Naruse, Masae ; Ishizaki, Yasuki ; Ikenaka, Kazuhiro ; Tanaka, Aoi ; Hitoshi, Seiji
Assuntos: Animals ; Brain ; Brain damage ; Cell Differentiation - physiology ; Cerebral Cortex - cytology ; Cortex ; Cortex (temporal) ; Embryos ; Forebrain ; Gene expression ; Glial stem cells ; Humans ; Mammals ; Myelin ; Neural stem cells ; Neural Stem Cells - cytology ; Oligodendrocytes ; Oligodendroglia - cytology ; Regenerative medicine ; Review ; Rodents ; Stem cell transplantation ; Stem cells ; Transcription factors
É parte de: The journal of physiological sciences, 2017-01, Vol.67 (1), p.63-70
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Oligodendrocyte precursor cells (OPCs) appear in the late embryonic brain, mature into oligodendrocytes (OLs), and form myelin in the postnatal brain. It has been proposed that early born OPCs derived from the ventral forebrain are eliminated postnatally and late-born OLs predominate in the adult mouse cortex. However, the temporal and regional niche for cortical OL generation, which persists throughout life in adult mammals, remains to be determined. Our recent study provides new insight into self-renewing and multipotent neural stem cells (NSCs). Our results, together with previous studies, suggest that NSCs at the dorsoventral boundary are uniquely specialized to produce myelin-forming OLs in the cortex during a restricted temporal window. These findings may help identify transcription factors or gene expression patterns which confer neural precursors with the characteristic ability of dorsoventral boundary NSCs to differentiate into OLs, and facilitate the development of new strategies for regenerative medicine of the damaged brain.
Editor: Japan: Springer
Idioma: Inglês

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Origin of oligodendrocytes in mammalian forebrains: a revised perspective

Naruse, Masae ; Ishizaki, Yasuki ; Ikenaka, Kazuhiro ; Tanaka, Aoi ; Hitoshi, Seiji

Japan: Springer

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