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How Next-Generation Sequencing and Multiscale Data Analysis Will Transform Infectious Disease Management

Pak, Theodore R. ; Kasarskis, Andrew

Clinical infectious diseases, 2015-12, Vol.61 (11), p.1695-1702 [Periódico revisado por pares]

United States: Oxford University Press

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Título:
How Next-Generation Sequencing and Multiscale Data Analysis Will Transform Infectious Disease Management
Autor: Pak, Theodore R. ; Kasarskis, Andrew
Assuntos: Communicable Diseases - diagnosis ; Communicable Diseases - microbiology ; Communicable Diseases - therapy ; Computational Biology - methods ; Disease Management ; Electronic Health Records ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Infectious diseases ; Meta-Analysis as Topic ; Microbiology ; Multidrug resistant organisms ; Sequence Analysis, DNA - methods ; Software ; VIEWPOINTS
É parte de: Clinical infectious diseases, 2015-12, Vol.61 (11), p.1695-1702
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: Recent reviews have examined the extent to which routine next-generation sequencing (NGS) on clinical specimens will improve the capabilities of clinical microbiology laboratories in the short term, but do not explore integrating NGS with clinical data from electronic medical records (EMRs), immune profiling data, and other rich datasets to create multiscale predictive models. This review introduces a range of "omics" and patient data sources relevant to managing infections and proposes 3 potentially disruptive applications for these data in the clinical workflow. The combined threats of healthcare-associated infections and multidrug-resistant organisms may be addressed by multiscale analysis of NGS and EMR data that is ideally updated and refined over time within each healthcare organization. Such data and analysis should form the cornerstone of future learning health systems for infectious disease.
Editor: United States: Oxford University Press
Idioma: Inglês

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How Next-Generation Sequencing and Multiscale Data Analysis Will Transform Infectious Disease Management

Pak, Theodore R. ; Kasarskis, Andrew

United States: Oxford University Press

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