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Synthesis, characterization and protection effect of black rice anthocyanins nano-composite against hepatotoxicity induced by methotrexate in rats/Sintese, caracterizacao e efeito protetor de nanocomposito de antocianinas de arroz preto contra hepatotoxicidade induzida por metotrexato em ratos

Sheikha, M.A ; Soheir, N.A ; SyragEldin, F.M

Brazilian journal of biology, 2024-01, Vol.84 [Periódico revisado por pares]

Association of the Brazilian Journal of Biology

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  • Título:
    Synthesis, characterization and protection effect of black rice anthocyanins nano-composite against hepatotoxicity induced by methotrexate in rats/Sintese, caracterizacao e efeito protetor de nanocomposito de antocianinas de arroz preto contra hepatotoxicidade induzida por metotrexato em ratos
  • Autor: Sheikha, M.A ; Soheir, N.A ; SyragEldin, F.M
  • Assuntos: Animal experimentation ; Anthocyanin ; Low density lipoproteins ; Methotrexate
  • É parte de: Brazilian journal of biology, 2024-01, Vol.84
  • Descrição: The present study aimed to investigate the beneficial of prepared black rice anthocyanins nano-composite (An- Ag[Np.sub.s]) against hepatotoxicity induced by methotrexate (MTX) in rats. Anthocyanins nano-composite was prepared by silver as the metallic ion reduction and were characterized by IR and SEM. The rats in our experiment were divided into five groups. Serum lipid profile, serum transaminases (ALT and AST), ALP, LDH, TBA, GSH and SOD were examined. The results show that SEM of An-Ag[Np.sub.s] has average particle size from 70 to 130nm. In the group treated with MTX; TC, TG, LDL-c, ALT, AST, ALP, LDH and TBA levels were significantly (P[less than or equal to]0.05) increased than NC, while, HDL-c, SOD and GSH levels were significantly (P[less than or equal to]0.05) decreased. On the other hand, An-Ag[Np.sub.s] + MTX treated groups were reversed the levels of all biomarkers similar to NC. In conclusion, the results show that AnAg[Np.sub.s] has a protective effect on MTX-induced hepatotoxicity and oxidative stress.
  • Editor: Association of the Brazilian Journal of Biology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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