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Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules

Boissenot, Tanguy ; Bordat, Alexandre ; Larrat, Benoît ; Varna, Mariana ; Chacun, Hélène ; Paci, Angelo ; Poinsignon, Vianney ; Fattal, Elias ; Tsapis, Nicolas

Journal of controlled release, 2017-10, Vol.264, p.219-227 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules
Autor: Boissenot, Tanguy ; Bordat, Alexandre ; Larrat, Benoît ; Varna, Mariana ; Chacun, Hélène ; Paci, Angelo ; Poinsignon, Vianney ; Fattal, Elias ; Tsapis, Nicolas
Assuntos: Acoustics ; Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacokinetics ; Antineoplastic Agents, Phytogenic - therapeutic use ; Bioengineering ; Cell Line, Tumor ; Chemical Sciences ; Combined Modality Therapy ; Female ; Fluorocarbons - administration & dosage ; Fluorocarbons - pharmacokinetics ; Fluorocarbons - therapeutic use ; Hyperthermia ; Hyperthermia, Induced ; Imaging ; Life Sciences ; Mechanics ; Medication ; Mice, Nude ; Nanocapsules ; Nanocapsules - administration & dosage ; Nanocapsules - therapeutic use ; Neoplasms - metabolism ; Neoplasms - therapy ; Paclitaxel ; Paclitaxel - administration & dosage ; Paclitaxel - pharmacokinetics ; Paclitaxel - therapeutic use ; Perfluorcarbons ; Pharmaceutical sciences ; Pharmacology ; Physics ; Polyethylene Glycols - administration & dosage ; Polyethylene Glycols - pharmacokinetics ; Polyethylene Glycols - therapeutic use ; Polyglactin 910 - administration & dosage ; Polyglactin 910 - pharmacokinetics ; Polyglactin 910 - therapeutic use ; Polymers ; Tissue Distribution ; Treatment Outcome ; Ultrasonic Therapy ; Ultrasound
É parte de: Journal of controlled release, 2017-10, Vol.264, p.219-227
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We study the influence of ultrasound on paclitaxel-loaded nanocapsules in vitro and in vivo. These nanocapsules possess a shell of poly(dl-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) and a liquid core of perfluorooctyl bromide (PFOB). In vitro experiments show that mechanical effects such as cavitation are negligible for nanocapsules due to their small size and thick and rigid shell. As the mechanical effects were unable to increase paclitaxel delivery, we focused on the thermal effects of ultrasound in the in vivo studies. A focused ultrasound sequence was therefore optimized in vivo under magnetic resonance imaging guidance to obtain localized mild hyperthermia with high acoustic pressure. Ultrasound-induced mild hyperthermia (41–43°C) was then tested in vivo in a subcutaneous CT-26 colon cancer murine model. As hyperthermia is applied, an inhibition of tumor growth for both paclitaxel-loaded nanocapsules and the commercial formulation of paclitaxel, namely Taxol® have been observed (p<0.05). Ultrasound-induced mild hyperthermia at high acoustic pressure appears as an interesting strategy to enhance cytotoxic efficacy locally. [Display omitted]
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules

Boissenot, Tanguy ; Bordat, Alexandre ; Larrat, Benoît ; Varna, Mariana ; Chacun, Hélène ; Paci, Angelo ; Poinsignon, Vianney ; Fattal, Elias ; Tsapis, Nicolas

Netherlands: Elsevier B.V

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