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Rat subcutaneous tissue response to calcium silicate containing different arsenic concentrations

Minotti, Paloma Gagliardi ; Ordinola-Zapata, Ronald ; Midena, Raquel Zanin ; Marciano, Marina Angélica ; Cavenago, Bruno Cavalini ; Bramante, Clovis Monteiro ; Garcia, Roberto Brandão ; Duarte, Marco Antonio Hungaro ; Moraes, Ivaldo Gomes de

Journal of applied oral science, 2015-01, Vol.23 (1), p.42-48 [Periódico revisado por pares]

Brazil: Faculdade de Odontologia de Bauru da Universidade de São Paulo

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Título:
Rat subcutaneous tissue response to calcium silicate containing different arsenic concentrations
Autor: Minotti, Paloma Gagliardi ; Ordinola-Zapata, Ronald ; Midena, Raquel Zanin ; Marciano, Marina Angélica ; Cavenago, Bruno Cavalini ; Bramante, Clovis Monteiro ; Garcia, Roberto Brandão ; Duarte, Marco Antonio Hungaro ; Moraes, Ivaldo Gomes de
Assuntos: Animals ; Arsenic ; Arsenic - administration & dosage ; Arsenic - toxicity ; Bismuth - chemistry ; Bismuth - toxicity ; Blood Vessels - drug effects ; Calcium Compounds - toxicity ; Collagen - drug effects ; Dental Cements - chemistry ; Dental Cements - toxicity ; Dental materials ; DENTISTRY, ORAL SURGERY & MEDICINE ; Endodontics ; Fibroblasts - drug effects ; Male ; Materials Testing ; Original ; Oxides - chemistry ; Oxides - toxicity ; Polyethylene - chemistry ; Portland cement ; Rats, Wistar ; Reference Values ; Silicates - toxicity ; Spectrophotometry, Atomic ; Subcutaneous Tissue - drug effects ; Subcutaneous tissue reaction ; Time Factors
É parte de: Journal of applied oral science, 2015-01, Vol.23 (1), p.42-48
Descrição: To evaluate the response of rat subcutaneous tissue in implanted polyethylene tubes that were filled with GMTA Angelus and Portland cements containing different arsenic concentrations. Atomic absorption spectrophotometry was utilized to obtain the values of the arsenic concentration in the materials. Thirty-six rats were divided into 3 groups of 12 animals for each experimental period. Each animal received two implants of polyethylene tubes filled with different test cements and the lateral of the tubes was used as a control group. After 15, 30 and 60 days of implantation, the animals were killed and the specimens were prepared for descriptive and morphometric analysis considering: inflammatory cells, collagen fibers, fibroblasts, blood vessels and other components. The results were analyzed utilizing the Kuskal-Wallis test and the Dunn's Multiple test for comparison (p<0.05). The materials showed, according to atomic absorption spectrophotometry, the following doses of arsenic: GMTA Angelus: 5.01 mg/kg, WPC Irajazinho: 0.69 mg/kg, GPC Minetti: 18.46 mg/kg and GPC Votoran: 10.76 mg/kg. In a 60-day periods, all specimens displayed a neoformation of connective tissue with a structure of fibrocellular aspect (capsule). Control groups and MTA Angelus produced the lower amount of inflammatory reaction and GPC Minetti, the highest reaction. There was no direct relationship between the concentration of arsenic present in the composition of the materials and the intensity of the inflammatory reactions. Higher values, as 18.46 mg/kg of arsenic in the cement, produce characteristics of severe inflammation reaction at the 60-day period. The best results were found in MTA angelus.
Editor: Brazil: Faculdade de Odontologia de Bauru da Universidade de São Paulo
Idioma: Inglês;Português

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Rat subcutaneous tissue response to calcium silicate containing different arsenic concentrations

Minotti, Paloma Gagliardi ; Ordinola-Zapata, Ronald ; Midena, Raquel Zanin ; Marciano, Marina Angélica ; Cavenago, Bruno Cavalini ; Bramante, Clovis Monteiro ; Garcia, Roberto Brandão ; Duarte, Marco Antonio Hungaro ; Moraes, Ivaldo Gomes de

Brazil: Faculdade de Odontologia de Bauru da Universidade de São Paulo

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