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In vitro evaluation of the cytotoxicity and eye irritation potential of preservatives widely used in cosmetics

Gabriela De Oliveira Prado Corrêa; Danieli Camilo Marcato; Wagner Soares Ramos; Marcos Antônio Corrêa; Vera Lucia Borges Isaac

Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)

Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 2023-07-10

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  • Título:
    In vitro evaluation of the cytotoxicity and eye irritation potential of preservatives widely used in cosmetics
  • Autor: Gabriela De Oliveira Prado Corrêa; Danieli Camilo Marcato; Wagner Soares Ramos; Marcos Antônio Corrêa; Vera Lucia Borges Isaac
  • Assuntos: Preservatives; Cosmetics; Cell Culture; Cytotoxicity; Het-Cam Test
  • É parte de: Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
  • Descrição: The consumption of cosmetics has been increasing every year and is expected to reach $675 billion by 2020 at an estimated growth rate of 6.4% per year. Exposure to skin irritants is the major cause of non-immunological inflammation of the skin. Therefore, the safety evaluation of cosmetic preservatives should be increased. Thus, the present work aimed to evaluate the cytotoxicity as the viability endpoint and the eye irritation potential of preservatives used in cosmetics. Cytotoxicity assays were performed using MTT and NRU in human keratinocytes (HaCaT), human dermal fibroblasts, adult (HDFa), and human hepatoma cells (HepG2). The eye irritation potential was evaluated using the Hen’s Egg Test-chorioallantoic membrane (HET-CAM). The evaluated preservatives were methylparaben (MP), propylparaben (PP), phenoxyethanol (PE), and a mixture of methylchloroisothiazolinone and methylisothiazolinone (CMI/MI). All preservatives showed cytotoxic potential within the permitted concentrations for use in cosmetic products. In the HET-CAM test, PE and CMI/MI, MP, and PP were classified as severe, moderate, and poor irritants, respectively. Our results indicate that proper safety evaluations are required to ensure the beneficial properties of preservatives on cosmetic products without exceeding exposure levels that would result in adverse health effects for consumers.
  • Títulos relacionados: https://www.revistas.usp.br/bjps/article/view/214203/196437
  • Editor: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
  • Data de criação/publicação: 2023-07-10
  • Formato: Adobe PDF
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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