Idioma:

The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families

Prandini, Paola ; Pasquali, Alessandra ; Malerba, Giovanni ; Marostica, Andrea ; Zusi, Chiara ; Xumerle, Luciano ; Muglia, Pierandrea ; Da Ros, Lucio ; Ratti, Emiliangelo ; Trabetti, Elisabetta ; Pignatti, Pier Franco

Psychiatric genetics, 2012-08, Vol.22 (4), p.177-181 [Periódico revisado por pares]

England

Texto completo disponível

Citações Citado por

Enviar para

Título:
The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families
Autor: Prandini, Paola ; Pasquali, Alessandra ; Malerba, Giovanni ; Marostica, Andrea ; Zusi, Chiara ; Xumerle, Luciano ; Muglia, Pierandrea ; Da Ros, Lucio ; Ratti, Emiliangelo ; Trabetti, Elisabetta ; Pignatti, Pier Franco
Assuntos: Autism ; Case-Control Studies ; Child Development Disorders, Pervasive - genetics ; Child, Preschool ; Communication ; En2 gene ; Family ; Female ; Genetic Association Studies ; Genetic markers ; Genetic Predisposition to Disease ; Humans ; Italy ; Male ; Pitx1 gene ; Polymorphism, Single Nucleotide - genetics ; Reproducibility of Results ; Single-nucleotide polymorphism
É parte de: Psychiatric genetics, 2012-08, Vol.22 (4), p.177-181
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
Descrição: The objective of this study was to replicate an association study on a newly collected Italian autism spectrum disorder (ASD) cohort by studying the genetic markers associated with ASDs from recent genome-wide and candidate gene association studies. We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). A family-based association study was conducted. A significant association was found for two of seven markers: rs4307059 T allele (odds ratio: 1.758, SE=0.236; P-value=0.017) and rs35678 TC genotype (odds ratio: 0.528, SE=0.199; P-value=0.0013). A preferential allele transmission of two markers located at loci previously associated with social and verbal communication skill has been confirmed in patients of a new ASD family sample.
Editor: England
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families

Prandini, Paola ; Pasquali, Alessandra ; Malerba, Giovanni ; Marostica, Andrea ; Zusi, Chiara ; Xumerle, Luciano ; Muglia, Pierandrea ; Da Ros, Lucio ; Ratti, Emiliangelo ; Trabetti, Elisabetta ; Pignatti, Pier Franco

England

Buscando em bases de dados remotas. Favor aguardar.