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Hematopoietic stem cell stretches and moves in its bone marrow niche

Silva, Walison N. ; Costa, Alinne C. ; Picoli, Caroline C. ; Rocha, Beatriz G.S. ; Santos, Gabryella S.P. ; Costa, Pedro A.C. ; Azimnasab-sorkhabi, Parviz ; Soltani-asl, Maryam ; da Silva, Rodrigo A. ; Amorim, Jaime Henrique ; Resende, Rodrigo R. ; Mintz, Akiva ; Birbrair, Alexander

Critical reviews in oncology/hematology, 2021-07, Vol.163, p.103368-103368, Article 103368 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Hematopoietic stem cell stretches and moves in its bone marrow niche
Autor: Silva, Walison N. ; Costa, Alinne C. ; Picoli, Caroline C. ; Rocha, Beatriz G.S. ; Santos, Gabryella S.P. ; Costa, Pedro A.C. ; Azimnasab-sorkhabi, Parviz ; Soltani-asl, Maryam ; da Silva, Rodrigo A. ; Amorim, Jaime Henrique ; Resende, Rodrigo R. ; Mintz, Akiva ; Birbrair, Alexander
Assuntos: Animals ; Bone Marrow ; Bone Marrow Cells ; Cell Division ; Hematopoietic Stem Cells ; Humans ; Microenvironment ; Niche ; Stem Cell Niche ; Two-photon laser scanning microscopy
É parte de: Critical reviews in oncology/hematology, 2021-07, Vol.163, p.103368-103368, Article 103368
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
co-first authors
Descrição: [Display omitted] •Hematopoietic stem cell retained steady state within the bone marrow niche is linked to a mobile behavior.•The heterogeneity of hematopoietic stem cells bone marrow niche.•Hematopoietic stem cells’ displacement velocity in the bone marrow faster than macrophages. Hematopoietic stem cells are the most illustrious inhabitants of the bone marrow. Direct visualization of endogenous hematopoietic stem cells in this niche is essential to study their functions. Until recently this was not possible in live animals. Recent studies, using state-of-the-art technologies, including sophisticated in vivo inducible genetic approaches in combination with two-photon laser scanning microscopy, allow the follow-up of endogenous hematopoietic stem cells’ behavior in their habitat. Strikingly, the new findings reveal that quiescent hematopoietic stem cells are more mobile than previously thought, and link their retained steady state within the niche to a mobile behavior. The arising knowledge from this research will be critical for the therapy of several hematological diseases. Here, we review recent progress in our understanding of hematopoietic stem cell biology in their niches.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Hematopoietic stem cell stretches and moves in its bone marrow niche

Silva, Walison N. ; Costa, Alinne C. ; Picoli, Caroline C. ; Rocha, Beatriz G.S. ; Santos, Gabryella S.P. ; Costa, Pedro A.C. ; Azimnasab-sorkhabi, Parviz ; Soltani-asl, Maryam ; da Silva, Rodrigo A. ; Amorim, Jaime Henrique ; Resende, Rodrigo R. ; Mintz, Akiva ; Birbrair, Alexander

Netherlands: Elsevier B.V

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