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Natural products targeting FcεRI receptor for anti‐allergic therapeutics

Vo, Thanh Sang

Journal of food biochemistry, 2020-08, Vol.44 (8), p.e13335-n/a [Periódico revisado por pares]

United States

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  • Título:
    Natural products targeting FcεRI receptor for anti‐allergic therapeutics
  • Autor: Vo, Thanh Sang
  • Assuntos: allergy ; FcεRI ; green tea ; natural products ; seaweed
  • É parte de: Journal of food biochemistry, 2020-08, Vol.44 (8), p.e13335-n/a
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Mast cells and basophils are important contributors for development of allergic reactions. The activation of these cells via cross‐linking of IgE bound to FcεRI by allergen causes the generation of allergic mediators and the reaction of immediate hypersensitivity. Obviously, FcεRI is considered as a key trigger of acute allergic responses. Consequently, FcεRI is regarded as a potential target for downregulation of allergic diseases. So far, numerous synthetic agents have been reported for inhibition of FcεRI expression and FcεRI‐IgE interaction. Meanwhile, natural products have received much attention due to their efficacy and safety. Recently, numerous anti‐allergic agents from natural products have been revealed as promising inhibitors of allergic reactions via inhibiting the expression of FcεRI subunits as well as blocking FcεRI activation. Thus, the present contribution is mainly focused to describe natural products targeting FcεRI receptor and to emphasize their applicable potential as anti‐allergic foods. Practical applications Phlorotannins, epigallocatechin‐3‐gallate, peptides, chitooligosaccharides, and other natural products have been revealed as potential inhibitors of allergic responses. These bioactive agents target to FcεRI receptor by inhibiting expression of FcεRI and blocking interaction of FcεRI‐IgE. Hence, these compounds could be applied as functional ingredients of anti‐allergic foods. Allergic diseases are known as an IgE‐mediated immune response to an innocuous environmental antigen. Especially, FcεRI expressing on the cell surface of mast cells and basophils is considered as a key trigger of acute allergic responses. Recently, numerous bioactive agents derived from natural products have been revealed to inhibit the expression of FcεRI subunits as well as block FcεRI activation. Thus, the present contribution is mainly focused to describe natural products targeting FcεRI receptor and to emphasize their applicable potential as anti‐allergic foods.
  • Editor: United States
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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