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Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

Rajani, Rikesh M ; Quick, Sophie ; Ruigrok, Silvie R ; Graham, Delyth ; Harris, Sarah E ; Verhaaren, Benjamin F J ; Fornage, Myriam ; Seshadri, Sudha ; Atanur, Santosh S ; Dominiczak, Anna F ; Smith, Colin ; Wardlaw, Joanna M ; Williams, Anna

Science translational medicine, 2018-07, Vol.10 (448) [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats
Autor: Rajani, Rikesh M ; Quick, Sophie ; Ruigrok, Silvie R ; Graham, Delyth ; Harris, Sarah E ; Verhaaren, Benjamin F J ; Fornage, Myriam ; Seshadri, Sudha ; Atanur, Santosh S ; Dominiczak, Anna F ; Smith, Colin ; Wardlaw, Joanna M ; Williams, Anna
Assuntos: Adenosine Triphosphatases - genetics ; Aging ; Animals ; Blood vessels ; Blood-brain barrier ; Blood-Brain Barrier - pathology ; Blood-Brain Barrier - physiopathology ; Cell Proliferation ; Cerebral Small Vessel Diseases - pathology ; Cerebral Small Vessel Diseases - physiopathology ; Dementia disorders ; Disease Models, Animal ; Endothelial cells ; Endothelial Cells - pathology ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Geriatrics ; Heat shock proteins ; Homozygote ; HSP90 Heat-Shock Proteins - metabolism ; Hsp90 protein ; Humans ; Hypertension - pathology ; Hypertension - physiopathology ; Membrane Transport Proteins - genetics ; Middle Aged ; Myelination ; Oligodendrocyte Precursor Cells - metabolism ; Polymorphism, Single Nucleotide - genetics ; Rats ; Single-nucleotide polymorphism ; Substantia alba ; Vascular diseases ; White Matter - pathology ; White Matter - physiopathology
É parte de: Science translational medicine, 2018-07, Vol.10 (448)
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SourceType-Scholarly Journals-1
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Descrição: Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we do not understand the mechanistic pathological link between blood vessels and white matter myelin damage. Hypertension is suggested as the cause of sporadic SVD, but a recent alternative hypothesis invokes dysfunction of the blood-brain barrier as the primary cause. In a rat model of SVD, we show that endothelial cell (EC) dysfunction is the first change in development of the disease. Dysfunctional ECs secrete heat shock protein 90α, which blocks oligodendroglial differentiation, contributing to impaired myelination. Treatment with EC-stabilizing drugs reversed these EC and oligodendroglial pathologies in the rat model. EC and oligodendroglial dysfunction were also observed in humans with early, asymptomatic SVD pathology. We identified a loss-of-function mutation in ATPase11B, which caused the EC dysfunction in the rat SVD model, and a single-nucleotide polymorphism in ATPase11B that was associated with white matter abnormalities in humans with SVD. We show that EC dysfunction is a cause of SVD white matter vulnerability and provide a therapeutic strategy to treat and reverse SVD in the rat model, which may also be of relevance to human SVD.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

Rajani, Rikesh M ; Quick, Sophie ; Ruigrok, Silvie R ; Graham, Delyth ; Harris, Sarah E ; Verhaaren, Benjamin F J ; Fornage, Myriam ; Seshadri, Sudha ; Atanur, Santosh S ; Dominiczak, Anna F ; Smith, Colin ; Wardlaw, Joanna M ; Williams, Anna

United States: The American Association for the Advancement of Science

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