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Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans

Lim, S K ; Park, Y S ; Park, J M ; Song, Y D ; Lee, E J ; Kim, K R ; Lee, H C ; Huh, K B

Journal of Clinical Endocrinology and Metabolism, 1995-12, Vol.80 (12), p.3677-3681 [Periódico revisado por pares]

Bethesda, MD: Endocrine Society

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Título:
Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans
Autor: Lim, S K ; Park, Y S ; Park, J M ; Song, Y D ; Lee, E J ; Kim, K R ; Lee, H C ; Huh, K B
Assuntos: Adult ; Asian Continental Ancestry Group ; Biological and medical sciences ; BIOLOGY AND MEDICINE, BASIC STUDIES ; CALCIUM ; Diseases of the osteoarticular system ; Female ; FEMALES ; GENE MUTATIONS ; GENES ; GENOTYPE ; HEREDITARY DISEASES ; Humans ; INTESTINAL ABSORPTION ; Korea - ethnology ; Medical sciences ; Middle Aged ; Osteocalcin - blood ; OSTEOPOROSIS ; Osteoporosis - blood ; Osteoporosis - genetics ; Osteoporosis. Osteomalacia. Paget disease ; PHENOTYPE ; POLYMERASE CHAIN REACTION ; RECEPTORS ; Receptors, Calcitriol - genetics ; Reference Values ; REPUBLIC OF KOREA ; RFLPS ; SCREENING ; STATISTICS ; STRUCTURE-ACTIVITY RELATIONSHIPS ; Tropical medicine ; VITAMIN D
É parte de: Journal of Clinical Endocrinology and Metabolism, 1995-12, Vol.80 (12), p.3677-3681
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To evaluate whether common allelic variants in the gene encoding the vitamin D receptor (VDR) were useful in predicting differences in bone mineral density (BMD) and bone turnover rate in Koreans, we analyzed the restriction pattern of the polymerase chain reaction product of the VDR gene with the Bsm1 enzyme and serum osteocalcin in patients with osteoporosis. The prevalence of the BB genotype in the controls was extremely low when compared with that in other reports: the BB, Bb, and bb genotypes accounted for 1.4%, 12.9%, and 85.7%, respectively. Only 2.8% of those patients with osteoporosis had the BB genotype. In contrast, 12.5% had the Bb genotype, and 84.7% had the bb genotype. The prevalence of the BB genotype in patients with severe osteoporosis was also extremely low: the BB, Bb, and bb genotypes accounted for 0%, 12.4%, and 87.6%, respectively. Compared with the mean serum osteocalcin level of the pre- and post-menopausal controls, the level in patients with severe osteoporosis was higher, and this was statistically significant. As expected, a negative correlation was observed between the serum osteocalcin levels and the age-matched Z scores for spinal BMD. However, no correlation was found in the femoral neck BMD. These results suggest that restriction fragment length polymorphism analysis of the VDR gene with a Bsm1 restriction enzyme in Koreans is not helpful for early detection of patients at risk of developing osteoporosis. This is true even in patients with a high rate of bone turnover. Our data suggest extreme ethnic differences in the pattern of prevalence of the VDR allele.
Editor: Bethesda, MD: Endocrine Society
Idioma: Inglês

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Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans

Lim, S K ; Park, Y S ; Park, J M ; Song, Y D ; Lee, E J ; Kim, K R ; Lee, H C ; Huh, K B

Bethesda, MD: Endocrine Society

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