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Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging

Park, Chan Hum ; Tanaka, Takashi ; Kim, Hyun Young ; Park, Jong Cheol ; Yokozawa, Takako Patwardhan, Bhushan ; Bhushan Patwardhan

Evidence-based complementary and alternative medicine, 2012-01, Vol.2012, p.418953-7 [Periódico revisado por pares]

United States: Hindawi Publishing Corporation

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  • Título:
    Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging
  • Autor: Park, Chan Hum ; Tanaka, Takashi ; Kim, Hyun Young ; Park, Jong Cheol ; Yokozawa, Takako
  • Patwardhan, Bhushan ; Bhushan Patwardhan
  • Assuntos: Advanced glycosylation end products ; Age ; Antioxidants ; Chromatography ; Commelina benghalensis ; Diabetes ; Fluorescence ; Free radicals ; Glycosylation ; Hyperglycemia ; Inhibition ; Low molecular weights ; Metabolism ; Molecular chains ; Molecular weight ; Oxidative stress ; Polyphenols ; Proanthocyanidins ; Rodents ; Vitamin E
  • É parte de: Evidence-based complementary and alternative medicine, 2012-01, Vol.2012, p.418953-7
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Academic Editor: Bhushan Patwardhan
  • Descrição: We investigated the inhibition of advanced glycation endproduct (AGE) activity using the fluorescence characteristics of fractions and compounds from Corni Fructus. Corni Fructus extract and its iridoid glycoside components showed low inhibitory activities as well as the AGE inhibitor aminoguanidine. However, a low molecular weight polyphenol, 7-O-galloyl-D-sedoheptulose, and an antioxidant, trolox, showed high inhibitory activities compared with aminoguanidine under reactive conditions. The AGE-inhibiting activity of polyphenolic fractions of Corni Fructus ranged from a level comparable to Corni Fructus extract to the higher level of 7-O-galloyl-D-sedoheptulose. As well as the results of AGE-inhibiting activity, Corni Fructus extract and iridoid components showed low or no 1,1-diphenyl-2-pycrylhydrazyl (DPPH) radical-scavenging activities, whereas 7-O-galloyl-D-sedoheptulose showed a level comparable to trolox. Polyphenolic fractions of Corni Fructus quenched DPPH radicals in a concentration-dependent manner. Some fractions exerted a higher DPPH radical-scavenging activity compared with trolox and 7-O-galloyl-D-sedoheptulose. The DPPH radical-scavenging activity was significantly correlated with the AGE-inhibiting activity. These results suggest that polyphenolic fractions of Corni Fructus inhibited AGE formation by antioxidant activity including free radical scavenging. The strong DPPH radical-scavenging and AGE-inhibiting fractions included ellagitannins and polymeric proanthocyanidins.
  • Editor: United States: Hindawi Publishing Corporation
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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