Idioma:

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Damborská, Alena ; Honzírková, Eliška ; Barteček, Richard ; Hořínková, Jana ; Fedorová, Sylvie ; Ondruš, Šimon ; Michel, Christoph M ; Rubega, Maria

Scientific reports, 2020-03, Vol.10 (1), p.4398-4398, Article 4398 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
Autor: Damborská, Alena ; Honzírková, Eliška ; Barteček, Richard ; Hořínková, Jana ; Fedorová, Sylvie ; Ondruš, Šimon ; Michel, Christoph M ; Rubega, Maria
Assuntos: Adult ; Amygdala ; Amygdala - physiopathology ; Brain Mapping - methods ; Case-Control Studies ; Deep Brain Stimulation ; Depression - physiopathology ; Depression - therapy ; EEG ; Efficiency ; Electroencephalography ; Female ; Globus pallidus ; Humans ; Image Processing, Computer-Assisted ; Male ; Mental depression ; Middle Aged ; Neostriatum ; Nervous system ; Neural networks ; Neural Pathways - diagnostic imaging ; Neural Pathways - physiopathology ; Neurosciences ; Putamen ; Thalamus
É parte de: Scientific reports, 2020-03, Vol.10 (1), p.4398-4398, Article 4398
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p < 0.001) in patients than in controls. The global efficiency was significantly higher (p < 0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake ([Formula: see text]). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Damborská, Alena ; Honzírková, Eliška ; Barteček, Richard ; Hořínková, Jana ; Fedorová, Sylvie ; Ondruš, Šimon ; Michel, Christoph M ; Rubega, Maria

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.