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Complex Elucidation of Cells-of-Origin in Pediatric Soft Tissue Sarcoma: From Concepts to Real Life, Hide-and-Seek through Epigenetic and Transcriptional Reprogramming

Savary, Clara ; Picard, Cécile ; Corradini, Nadège ; Castets, Marie

International journal of molecular sciences, 2022-06, Vol.23 (11), p.6310 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Complex Elucidation of Cells-of-Origin in Pediatric Soft Tissue Sarcoma: From Concepts to Real Life, Hide-and-Seek through Epigenetic and Transcriptional Reprogramming
Autor: Savary, Clara ; Picard, Cécile ; Corradini, Nadège ; Castets, Marie
Assuntos: Cancer therapies ; cell-of-origin ; cellular reprogramming ; Chemotherapy ; Disease management ; DNA methylation ; Epigenetics ; Gene expression ; Heterogeneity ; Life Sciences ; Medical prognosis ; Mesenchyme ; Metastasis ; Morphology ; Mutation ; Pediatrics ; Phenotypes ; Proteins ; Questions ; Review ; Sarcoma ; Soft tissue sarcoma ; Soft tissues ; Transcription factors ; transcriptional networks ; transdifferentiation ; Tumorigenesis ; Tumors
É parte de: International journal of molecular sciences, 2022-06, Vol.23 (11), p.6310
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Soft tissue sarcoma (STS) comprise a large group of mesenchymal malignant tumors with heterogeneous cellular morphology, proliferative index, genetic lesions and, more importantly, clinical features. Full elucidation of this wide diversity remains a central question to improve their therapeutic management and the identity of cell(s)-of-origin from which these tumors arise is part of this enigma. Cellular reprogramming allows transitions of a mature cell between phenotypes, or identities, and represents one key driver of tumoral heterogeneity. Here, we discuss how cellular reprogramming mediated by driver genes in STS can profoundly reshape the molecular and morphological features of a transformed cell and lead to erroneous interpretation of its cell-of-origin. This review questions the fact that the epigenetic context in which a genetic alteration arises has to be taken into account as a key determinant of STS tumor initiation and progression. Retracing the cancer-initiating cell and its clonal evolution, notably via epigenetic approach, appears as a key lever for understanding the origin of these tumors and improving their clinical management.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Complex Elucidation of Cells-of-Origin in Pediatric Soft Tissue Sarcoma: From Concepts to Real Life, Hide-and-Seek through Epigenetic and Transcriptional Reprogramming

Savary, Clara ; Picard, Cécile ; Corradini, Nadège ; Castets, Marie

Switzerland: MDPI AG

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