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Expression of c-erbB2 oncogene protein as a prognostic factor in feline mammary tumors

Mataya Taweechart(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; On-uma Sirayayon(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Grisnarong Wongbandue(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Supradit Wangnaitham(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Achariya Sailasuta(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Sudson Sirividhayapong(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Obstetrics, Gynaecology and Reproduction) ; Anudep Rungsipipat(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology)

Wētchasān sattawaphāet, 2004-12 [Periódico revisado por pares]

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Título:
Expression of c-erbB2 oncogene protein as a prognostic factor in feline mammary tumors
Autor: Mataya Taweechart(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; On-uma Sirayayon(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Grisnarong Wongbandue(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Supradit Wangnaitham(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Achariya Sailasuta(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) ; Sudson Sirividhayapong(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Obstetrics, Gynaecology and Reproduction) ; Anudep Rungsipipat(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology)
Assuntos: Cats ; Genes ; Histopathology ; Immunological techniques ; Mammary glands ; Neoplasms ; Proteins
É parte de: Wētchasān sattawaphāet, 2004-12
Notas: TH
L74
Descrição: Study looked at the relationship between the expression of c-erbB2 oncogene protein, histological types, PCNA and AgNORs indices in feline mammary tumors. Sixty, surgically resected, mammary tumors from cat were collected and histological processed. The expression of c-erbB2 oncogene protein was detected by immunohistochemistry and revealed benign hyperplasia, adenosis and malignant groups. The c-erbB2 oncogene protein expression of malignant, feline mammary tumors was 41.67 percent (25/60) and divided into simple tubular ACC, 25 percent (6/24), simple papillary ACC, 78.6 percent (11/14), solid carcinoma, 26.7 percent (4/15) and cribiform carcinoma, 57.14 percent (4/7). There was statistically significantly differences (p0.05) in the expression of c-erbB2 oncogene protein between simple tubular ACC, compared with simple papillary ACC and simple papillary ACC and solid carcinomas. The expression of c-erbB2 oncogene protein in specimens, classified by histological malignancy grade revealed grade I, 42.11 percent and grade II, 41.46 percent but there was no statistically significant difference. An evaluation of proliferative marker shown by a mean (+-SD) of PCNA, was 34.63+-23.87 and the mean (+-SD) of AgNORs was 1.23+-0.18. There was no significantly difference between the PCNA and AgNORs index of both the histological types and the histological malignancy grades. However, a statistical difference of mean PCNA and AgNORs indices was noted in both c-erbB2 positive and c-erbB2 negative groups. The mean PCNA indices and AgNORs indices in c-erbB2 positive were 26.52+-18.68 and 1.12+-0.27 respectively, while c-erbB2 negative were 39.43+-26.24 and 1.28+-0.19 respectively. In conclusion, c-erbB2 oncogene protein expression is supposed to be an effective prognostic factor for adenocarcinoma subtypes of feline mammary tumors as it is in human and canine cases. However, integration of all the parameters (c-erbB2 oncogene protein, PCNA index, AgNORs index, histological types and clinical data) may achieve a more precise prognosis in feline mammary tumor cases.
Idioma: Tailandês

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Expression of c-erbB2 oncogene protein as a prognostic factor in feline mammary tumors

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