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Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis

Kühn, Simone ; Gallinat, Jürgen

Biological psychiatry (1969), 2013, Vol.73 (1), p.70-74 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis
Autor: Kühn, Simone ; Gallinat, Jürgen
Assuntos: Adult and adolescent clinical studies ; ALE ; Anxiety disorders. Neuroses ; Atrophy - pathology ; Biological and medical sciences ; Brain - pathology ; Case-Control Studies ; hippocampus ; Humans ; Image Processing, Computer-Assisted - methods ; Likelihood Functions ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - psychology ; Magnetic Resonance Imaging - statistics & numerical data ; Medical sciences ; meta-analysis ; Nerve Fibers, Unmyelinated - pathology ; Neuroimaging - methods ; Neuroimaging - psychology ; Neuroimaging - statistics & numerical data ; Post-traumatic stress disorder ; posttraumatic stress disorder ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Stress Disorders, Post-Traumatic - pathology ; trauma ; VBM
É parte de: Biological psychiatry (1969), 2013, Vol.73 (1), p.70-74
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Background Since the inception of the diagnosis posttraumatic stress disorder (PTSD), attempts have been undertaken to understand why only a subpopulation of individuals exposed to trauma develops PTSD. Cerebral gray matter reductions have been suggested to be a crucial pathobiological marker of PTSD. However, a quantitative meta-analysis of whole-brain voxel-based morphometry studies is lacking. Methods Here, we investigated concurrence across voxel-based morphometry studies in PTSD compared with trauma-exposed individuals without PTSD (all together nine studies with 319 subjects) by means of activation likelihood estimation. Results We identified brain regions of consistent gray matter reduction in anterior cingulate cortex, ventromedial prefrontal cortex, left temporal pole/middle temporal gyrus, and left hippocampus in PTSD patients compared with individuals exposed to trauma without PTSD. Conclusions This is the first quantitative whole-brain meta-analysis showing brain structure deficits in traumatized subjects with PTSD compared with trauma-exposed healthy control subjects. The gray matter deficit profile overlaps with brain networks of emotion processing, fear extinction, and emotion regulation known to be affected in PTSD. Although the data cannot clarify if this is a predisposition or a consequence of the disease, the results may facilitate the need to control for structural characteristics in future functional brain studies.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis

Kühn, Simone ; Gallinat, Jürgen

New York, NY: Elsevier Inc

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