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Early movement restriction affects the acquisition of neurodevelopmental reflexes in rat pups

Dupuis, Orlane ; Van Gaever, Melanie ; Montel, Valerie ; Dereumetz, Julie ; Coq, Jacques-Olivier ; Canu, Marie-Helene ; Dupont, Erwan

Brain research, 2024-04, Vol.1828, p.148773-148773, Article 148773 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Early movement restriction affects the acquisition of neurodevelopmental reflexes in rat pups
  • Autor: Dupuis, Orlane ; Van Gaever, Melanie ; Montel, Valerie ; Dereumetz, Julie ; Coq, Jacques-Olivier ; Canu, Marie-Helene ; Dupont, Erwan
  • Assuntos: Animals ; Animals, Newborn ; Central Nervous System ; Developmental milestones ; Humans ; Life Sciences ; Motor skills ; Neurodevelopmental Disorders ; Neurons ; Postnatal development ; Postural Balance ; Primitive reflex ; Rats ; Reflex ; Sedentary behavior ; Sensorimotor integration
  • É parte de: Brain research, 2024-04, Vol.1828, p.148773-148773, Article 148773
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
  • Descrição: [Display omitted] •Early sensorimotor restriction (SMR) affects muscle and brain development.•We determined the age of achievement of the main neurodevelopmental reflexes.•Early SMR induces a delay in motor development and in acquisition of reflexes.•Reflexes that require an efficient postural support are more affected. Childhood is a period of construction of the organism, during which interactions with the environment and regular physical activity are necessary for the maturation of the neuronal networks. An atypical sensorimotor activity during childhood (due to bed-rest or neurodevelopmental disorders) impacts the development of the neuromuscular system. A model of sensorimotor restriction (SMR) developed in rats has shown that casting pups’ hind limbs from postnatal day 1 (P1) to P28 induced a severe perturbation of motor behavior, due to muscle weakness as well as disturbances within the central nervous system. In the present study, our objective was to determine whether SMR affects the early postnatal ontogenesis. We explored the neuromuscular development through the determination of the age for achievement of the main neurodevelopmental reflexes, which represent reliable indicators of neurological and behavioral development. We also evaluated the maturation of postural control. Our results demonstrate that SMR induces a delay in the motor development, illustrated by a several days delay in the acquisition of a mature posture and in the acquisition reflexes: hind limb grasping, righting, hind limb placing, cliff avoidance, negative geotaxis. In conclusion, impaired physical activity and low interactions with environment during early development result in altered maturation of the nervous system.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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