Idioma:

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

Lindqvist, Daniel ; Wolkowitz, Owen M ; Picard, Martin ; Ohlsson, Lars ; Bersani, Francesco S ; Fernström, Johan ; Westrin, Åsa ; Hough, Christina M ; Lin, Jue ; Reus, Victor I ; Epel, Elissa S ; Mellon, Synthia H

Neuropsychopharmacology (New York, N.Y.), 2018-06, Vol.43 (7), p.1557-1564 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder
Autor: Lindqvist, Daniel ; Wolkowitz, Owen M ; Picard, Martin ; Ohlsson, Lars ; Bersani, Francesco S ; Fernström, Johan ; Westrin, Åsa ; Hough, Christina M ; Lin, Jue ; Reus, Victor I ; Epel, Elissa S ; Mellon, Synthia H
Assuntos: Adult ; Antidepressants ; Antioxidants ; Body mass ; Case-Control Studies ; Cell-Free Nucleic Acids - blood ; Cell-Free Nucleic Acids - drug effects ; Clinical Medicine ; Copy number ; Deoxyribonucleic acid ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - genetics ; DNA ; DNA Copy Number Variations - drug effects ; DNA Copy Number Variations - genetics ; DNA, Mitochondrial - drug effects ; DNA, Mitochondrial - genetics ; Female ; Genomes ; Glutathione ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Humans ; Klinisk medicin ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mental depression ; Mitochondrial DNA ; Mutation ; Neurosciences ; Peripheral blood mononuclear cells ; Peroxidase ; Pharmacology & Pharmacy ; Psychiatry ; Psykiatri ; Serotonin uptake inhibitors ; Serotonin Uptake Inhibitors - pharmacology ; Serotonin Uptake Inhibitors - therapeutic use ; Smoking ; Telomere Homeostasis - genetics ; Treatment Outcome ; White blood cells ; Young Adult
É parte de: Neuropsychopharmacology (New York, N.Y.), 2018-06, Vol.43 (7), p.1557-1564
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the mitochondrial genome released during cellular stress. Few studies have examined ccf-mtDNA in MDD, and no studies have tested its relationship with intracellular mtDNA-cn or with antidepressant treatment response. Here, mtDNA levels were quantified in parallel from: (i) PBMCs and (ii) cell-free plasma of 50 unmedicated MDD subjects and 55 controls, in parallel with PBMC telomere length (TL) and antioxidant enzyme glutathione peroxidase (GpX) activity. MtDNA measures were repeated in 19 MDD subjects after 8 weeks of open-label SSRI treatment. In analyses adjusted for age, sex, BMI, and smoking, MDD subjects had significantly elevated levels of ccf-mtDNA (F = 20.6, p = 0.00002). PBMC mtDNA-cn did not differ between groups (p > 0.4). In preliminary analyses, we found that changes in ccf-mtDNA with SSRI treatment differed between SSRI responders and non-responders (F = 6.47, p = 0.02), with the non-responders showing an increase in ccf-mtDNA and responders not changing. Baseline ccf-mtDNA was positively correlated with GpX (r = 0.32, p = 0.001), and PBMC mtDNA correlated positively with PBMC TL (r = 0.38, p = 0.0001). These data suggest that plasma ccf-mtDNA and PBMC mtDNA-cn reflect different cellular processes and that the former may be more reflective of certain aspects of MDD pathophysiology and of the response to SSRI antidepressants.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

Lindqvist, Daniel ; Wolkowitz, Owen M ; Picard, Martin ; Ohlsson, Lars ; Bersani, Francesco S ; Fernström, Johan ; Westrin, Åsa ; Hough, Christina M ; Lin, Jue ; Reus, Victor I ; Epel, Elissa S ; Mellon, Synthia H

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.